Three-compartmental model of a cell cycle and drug resistance in chemotherapy design

A. Swierniak; J. Smieja

Three-compartmental model of a cell cycle and drug resistance in chemotherapy design

Katedra Inżynierii i Biologii Systemów (RAU/RAU1)

Wyniki badań: Rozdział w książce/raport/materiał konferencyjny › Wkład w konferencję › recenzja

Abstrakt

This paper presents an approach to modelling of the cancer cell population that takes into account phase-specific chemotherapy and evolution of drug resistance stemming from gene amplification. It allows to analyse simultaneously these two aspects of chemotherapy that have been studied separately so far. The mathematical model is based on three compartments in the cell cycle and two drugs that are administered in different phases: a blocking and a killing agent. The task of finding the best chemotherapy protocol is given by an optimal control problem defined in l¹ space, which aims at killing the greatest number of cancer cells while simultaneously trying to minimise side effects of the drugs.

Język oryginału	angielski
Tytuł publikacji goszczącej	Proceedings of the IASTED International Conference on Biomedical Engineering
Redaktorzy	M.H. Hamza
Strony	71-76
Liczba stron	6
Status publikacji	Opublikowano - 2003
Wydarzenie	Proceedings of the IASTED International Conference on Biomedical Engineering - Salzburg, Austria Czas trwania: 25 cze 2003 → 27 cze 2003

Seria publikacji

Nazwa	Proceedings of the IASTED International Conference on Biomedical Engineering

Konferencja

Konferencja	Proceedings of the IASTED International Conference on Biomedical Engineering
Kraj/Terytorium	Austria
Miejscowość	Salzburg
Okres	25/06/03 → 27/06/03

Cele SDG ONZ

Ten wynik przyczynia się do realizacji następujących celów zrównoważonego rozwoju

Cel 3 Dobre zdrowie i dobre samopoczucie

Obszary tematyczne ASJC Scopus

Inżynieria ogólna

Inne pliki i linki

Link do publikacji w Scopus

Cytowanie

@inproceedings{c8e4d148271b42979f90f9a3ccfd4e82,

title = "Three-compartmental model of a cell cycle and drug resistance in chemotherapy design",

abstract = "This paper presents an approach to modelling of the cancer cell population that takes into account phase-specific chemotherapy and evolution of drug resistance stemming from gene amplification. It allows to analyse simultaneously these two aspects of chemotherapy that have been studied separately so far. The mathematical model is based on three compartments in the cell cycle and two drugs that are administered in different phases: a blocking and a killing agent. The task of finding the best chemotherapy protocol is given by an optimal control problem defined in l1 space, which aims at killing the greatest number of cancer cells while simultaneously trying to minimise side effects of the drugs.",

keywords = "Biomedical modelling, Drug resistance, Phase-specific chemotherapy",

author = "A. Swierniak and J. Smieja",

year = "2003",

language = "English",

isbn = "0889863539",

series = "Proceedings of the IASTED International Conference on Biomedical Engineering",

pages = "71--76",

editor = "M.H. Hamza",

booktitle = "Proceedings of the IASTED International Conference on Biomedical Engineering",

note = "Proceedings of the IASTED International Conference on Biomedical Engineering ; Conference date: 25-06-2003 Through 27-06-2003",

}

Swierniak, A & Smieja, J 2003, Three-compartmental model of a cell cycle and drug resistance in chemotherapy design. w MH Hamza (red.), Proceedings of the IASTED International Conference on Biomedical Engineering. Proceedings of the IASTED International Conference on Biomedical Engineering, str. 71-76, Proceedings of the IASTED International Conference on Biomedical Engineering, Salzburg, Austria, 25/06/03.

Three-compartmental model of a cell cycle and drug resistance in chemotherapy design. / Swierniak, A.; Smieja, J.
Proceedings of the IASTED International Conference on Biomedical Engineering. red. / M.H. Hamza. 2003. str. 71-76 (Proceedings of the IASTED International Conference on Biomedical Engineering).

Wyniki badań: Rozdział w książce/raport/materiał konferencyjny › Wkład w konferencję › recenzja

TY - GEN

T1 - Three-compartmental model of a cell cycle and drug resistance in chemotherapy design

AU - Swierniak, A.

AU - Smieja, J.

PY - 2003

Y1 - 2003

N2 - This paper presents an approach to modelling of the cancer cell population that takes into account phase-specific chemotherapy and evolution of drug resistance stemming from gene amplification. It allows to analyse simultaneously these two aspects of chemotherapy that have been studied separately so far. The mathematical model is based on three compartments in the cell cycle and two drugs that are administered in different phases: a blocking and a killing agent. The task of finding the best chemotherapy protocol is given by an optimal control problem defined in l1 space, which aims at killing the greatest number of cancer cells while simultaneously trying to minimise side effects of the drugs.

AB - This paper presents an approach to modelling of the cancer cell population that takes into account phase-specific chemotherapy and evolution of drug resistance stemming from gene amplification. It allows to analyse simultaneously these two aspects of chemotherapy that have been studied separately so far. The mathematical model is based on three compartments in the cell cycle and two drugs that are administered in different phases: a blocking and a killing agent. The task of finding the best chemotherapy protocol is given by an optimal control problem defined in l1 space, which aims at killing the greatest number of cancer cells while simultaneously trying to minimise side effects of the drugs.

KW - Biomedical modelling

KW - Drug resistance

KW - Phase-specific chemotherapy

UR - https://www.scopus.com/pages/publications/2642518164

M3 - Conference contribution

AN - SCOPUS:2642518164

SN - 0889863539

T3 - Proceedings of the IASTED International Conference on Biomedical Engineering

SP - 71

EP - 76

BT - Proceedings of the IASTED International Conference on Biomedical Engineering

A2 - Hamza, M.H.

T2 - Proceedings of the IASTED International Conference on Biomedical Engineering

Y2 - 25 June 2003 through 27 June 2003

ER -

Three-compartmental model of a cell cycle and drug resistance in chemotherapy design

Abstrakt

Seria publikacji

Konferencja

Cele SDG ONZ

Obszary tematyczne ASJC Scopus

Inne pliki i linki

Fingerprint

Cytowanie