The synthesis of 4-acylamino-1,2,4-triazole derivatives in the reaction of α-hydroxyacid hydrazides and orthoesters

The reaction of α-hydroxyacid hydrazides and orthoesters in ethanol-acetic acid solution has been studied and a series of 4-acylamino-1,2,4-triazoles has been obtained as the final products. Some acyclic intermediates: 1-acyl-2-ethoxymethylenehydrazines and N,N′-bis (methanecarbonylamino) formamidine derivative have been also separated during the process. The structures of products was confirmed by typical spectroscopic methods and X-ray analysis.