Synthesis, X-ray structure and antiproliferative activity of 3-benzylthio-4-propargylselenoquinoline

Stanislaw Boryczka; Maria Jastrzebska; Maria Nowak; Joachim Kusz; Roman Wrzalik; Joanna Wietrzyk; Malgorzata Matyja

doi:10.1007/s00044-009-9212-x

Synthesis, X-ray structure and antiproliferative activity of 3-benzylthio-4-propargylselenoquinoline

Stanislaw Boryczka
, Maria Jastrzebska
, Maria Nowak
, Joachim Kusz
, Roman Wrzalik
, Joanna Wietrzyk
, Malgorzata Matyja

Katedra Geotechniki i Dróg (RB/RB7)

Medical University of Silesia in Katowice
University of Silesia in Katowice
Polish Academy of Sciences

Wyniki badań: Wkład do czasopisma › Artykuł › recenzja

3 Cytowania z bazy Scopus

Abstrakt

Synthesis, antiproliferative activity and the X-ray single-crystal structure of the 3-benzylthio-4-propargylselenoquinoline are described. The title compound belongs to the group of the acetylenic derivatives of thioquinolines, which have been intensively investigated as a source of new anticancer agents. The comparative study regarding the X-ray structure, the molecular electrostatic potential analysis, and structure-activity relationship for the title compound and the 3-methylthio-4-propargylthioquinoline and 3-methylthio-4-propargylselenoquinoline are presented.

Język oryginału	angielski
Strony (od–do)	551-564
Liczba stron	14
Czasopismo	Medicinal Chemistry Research
Tom	19
Numer wydania	6
Identyfikatory DOI	https://doi.org/10.1007/s00044-009-9212-x
Status publikacji	Opublikowano - lip 2010

Cele SDG ONZ

Ten wynik przyczynia się do realizacji następujących celów zrównoważonego rozwoju

Cel 3 Dobre zdrowie i dobre samopoczucie

Obszary tematyczne ASJC Scopus

Ogólna farmakologia, toksykologia i farmacja
Chemia organiczna

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10.1007/s00044-009-9212-x

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Cytowanie

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title = "Synthesis, X-ray structure and antiproliferative activity of 3-benzylthio-4-propargylselenoquinoline",

abstract = "Synthesis, antiproliferative activity and the X-ray single-crystal structure of the 3-benzylthio-4-propargylselenoquinoline are described. The title compound belongs to the group of the acetylenic derivatives of thioquinolines, which have been intensively investigated as a source of new anticancer agents. The comparative study regarding the X-ray structure, the molecular electrostatic potential analysis, and structure-activity relationship for the title compound and the 3-methylthio-4-propargylthioquinoline and 3-methylthio-4-propargylselenoquinoline are presented.",

keywords = "Antiproliferative activity, Electrostatic potential, Structure-activity relationship",

author = "Stanislaw Boryczka and Maria Jastrzebska and Maria Nowak and Joachim Kusz and Roman Wrzalik and Joanna Wietrzyk and Malgorzata Matyja",

year = "2010",

month = jul,

doi = "10.1007/s00044-009-9212-x",

language = "English",

volume = "19",

pages = "551--564",

journal = "Medicinal Chemistry Research",

issn = "1054-2523",

publisher = "Springer",

number = "6",

}

TY - JOUR

T1 - Synthesis, X-ray structure and antiproliferative activity of 3-benzylthio-4-propargylselenoquinoline

AU - Boryczka, Stanislaw

AU - Jastrzebska, Maria

AU - Nowak, Maria

AU - Kusz, Joachim

AU - Wrzalik, Roman

AU - Wietrzyk, Joanna

AU - Matyja, Malgorzata

PY - 2010/7

Y1 - 2010/7

N2 - Synthesis, antiproliferative activity and the X-ray single-crystal structure of the 3-benzylthio-4-propargylselenoquinoline are described. The title compound belongs to the group of the acetylenic derivatives of thioquinolines, which have been intensively investigated as a source of new anticancer agents. The comparative study regarding the X-ray structure, the molecular electrostatic potential analysis, and structure-activity relationship for the title compound and the 3-methylthio-4-propargylthioquinoline and 3-methylthio-4-propargylselenoquinoline are presented.

AB - Synthesis, antiproliferative activity and the X-ray single-crystal structure of the 3-benzylthio-4-propargylselenoquinoline are described. The title compound belongs to the group of the acetylenic derivatives of thioquinolines, which have been intensively investigated as a source of new anticancer agents. The comparative study regarding the X-ray structure, the molecular electrostatic potential analysis, and structure-activity relationship for the title compound and the 3-methylthio-4-propargylthioquinoline and 3-methylthio-4-propargylselenoquinoline are presented.

KW - Antiproliferative activity

KW - Electrostatic potential

KW - Structure-activity relationship

UR - https://www.scopus.com/pages/publications/77956470835

U2 - 10.1007/s00044-009-9212-x

DO - 10.1007/s00044-009-9212-x

M3 - Article

AN - SCOPUS:77956470835

SN - 1054-2523

VL - 19

SP - 551

EP - 564

JO - Medicinal Chemistry Research

JF - Medicinal Chemistry Research

IS - 6

ER -

Synthesis, X-ray structure and antiproliferative activity of 3-benzylthio-4-propargylselenoquinoline

Abstrakt

Cele SDG ONZ

Obszary tematyczne ASJC Scopus

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