Synthesis of 2-deoxy-hexopyranosyl derivatives of uridine as donor substrate analogues for glycosyltransferases

Ilona Wandzik; Tadeusz Bieg; Marianna Czaplicka

doi:10.1016/j.bioorg.2009.08.001

Synthesis of 2-deoxy-hexopyranosyl derivatives of uridine as donor substrate analogues for glycosyltransferases

Ilona Wandzik
, Tadeusz Bieg
, Marianna Czaplicka

Katedra Chemii Organicznej, Bioorganicznej i Biotechnologii (RCH/RCH2)

Institute of Non-Ferrous Metals

Wyniki badań: Wkład do czasopisma › Artykuł › recenzja

14 Cytowania z bazy Scopus

Abstrakt

A series of 2-deoxy-hexopyranosyl derivatives of uridine have been synthesized as analogues of UDP-sugar. These compounds were tested as inhibitors against bovine β-1,4-galactosyltransferase I in fluorescent assays and showed no significant inhibition.

Język oryginału	angielski
Strony (od–do)	211-216
Liczba stron	6
Czasopismo	Bioorganic Chemistry
Tom	37
Numer wydania	6
Identyfikatory DOI	https://doi.org/10.1016/j.bioorg.2009.08.001
Status publikacji	Opublikowano - gru 2009

Obszary tematyczne ASJC Scopus

Biochemia
Biologia molekularna
Odkrywanie leków
Chemia organiczna

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10.1016/j.bioorg.2009.08.001

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Cytowanie

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title = "Synthesis of 2-deoxy-hexopyranosyl derivatives of uridine as donor substrate analogues for glycosyltransferases",

abstract = "A series of 2-deoxy-hexopyranosyl derivatives of uridine have been synthesized as analogues of UDP-sugar. These compounds were tested as inhibitors against bovine β-1,4-galactosyltransferase I in fluorescent assays and showed no significant inhibition.",

keywords = "Donor substrate analogues, Glycals, Glycosyltransferases",

author = "Ilona Wandzik and Tadeusz Bieg and Marianna Czaplicka",

year = "2009",

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AU - Wandzik, Ilona

AU - Bieg, Tadeusz

AU - Czaplicka, Marianna

PY - 2009/12

Y1 - 2009/12

N2 - A series of 2-deoxy-hexopyranosyl derivatives of uridine have been synthesized as analogues of UDP-sugar. These compounds were tested as inhibitors against bovine β-1,4-galactosyltransferase I in fluorescent assays and showed no significant inhibition.

AB - A series of 2-deoxy-hexopyranosyl derivatives of uridine have been synthesized as analogues of UDP-sugar. These compounds were tested as inhibitors against bovine β-1,4-galactosyltransferase I in fluorescent assays and showed no significant inhibition.

KW - Donor substrate analogues

KW - Glycals

KW - Glycosyltransferases

UR - https://www.scopus.com/pages/publications/70350780185

U2 - 10.1016/j.bioorg.2009.08.001

DO - 10.1016/j.bioorg.2009.08.001

M3 - Article

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AN - SCOPUS:70350780185

SN - 0045-2068

VL - 37

SP - 211

EP - 216

JO - Bioorganic Chemistry

JF - Bioorganic Chemistry

IS - 6

ER -

Synthesis of 2-deoxy-hexopyranosyl derivatives of uridine as donor substrate analogues for glycosyltransferases

Abstrakt

Obszary tematyczne ASJC Scopus

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