@inproceedings{5c90402b86ba4f848212ca2eee7af7ef,
title = "Simulation analysis of the homologous recombination repair distribution over the cell cycle",
abstract = "Double-strand breaks (DSBs) are repaired with the use of several distinct mechanisms. The most important of them are non-homologous end joining (NHEJ) and homologous recombination (HR). These mechanisms have different requirements and are characterized by different repair kinetics. Moreover, HR is restricted to S and G2 phases of the cell cycle, however it is still not clear how percentage of DSBs repaired by HR changes over the cell cycle. In this study we are trying to find the most suitable function describing participation of HR among other types of repair. Using our mathematical model, we simulate the response of average cell treated with ionizing radiation (IR) during G1 phase of the cell cycle. Our results show that the exact shape of the function describing percentage of HR is not as important as the fact that this function should be gradually increasing until at least half of the S phase.",
keywords = "ATM, DNA repair, Deterministic, HR, Mathematical model, Resection, Simulations",
author = "Monika Kurpas and Krzysztof Puszynski",
note = "Publisher Copyright: {\textcopyright} 2018, Springer International Publishing AG.; 20th Polish Conference on Biocybernetics and Biomedical Engineering, 2017 ; Conference date: 20-09-2017 Through 22-09-2017",
year = "2018",
doi = "10.1007/978-3-319-66905-2\_19",
language = "English",
isbn = "9783319669045",
series = "Advances in Intelligent Systems and Computing",
publisher = "Springer Verlag",
pages = "218--229",
editor = "Piotr Augustyniak and Ryszard Tadeusiewicz and Roman Maniewski",
booktitle = "Recent Developments and Achievements in Biocybernetics and Biomedical Engineering - Proceedings of the 20th Polish Conference on Biocybernetics and Biomedical Engineering, 2017",
address = "Germany",
}