Sensitivity of controllability conditions for models of combined anticancer therapy

Andrzej Swierniak; Jerzy Klamka

doi:10.2316/P.2015.826-017

Sensitivity of controllability conditions for models of combined anticancer therapy

Andrzej Swierniak
, Jerzy Klamka

Wyniki badań: Rozdział w książce/raport/materiał konferencyjny › Wkład w konferencję › recenzja

Abstrakt

We analyze sensitivity of sufficient conditions for local controllability for a class of models of treatment response to combined anticancer therapies. The combined therapy is understood as combination of direct anticancer strategy e.g. chemotherapy and indirect modality (in this case antiangiogenic therapy). Controllability of the models in the form of semilinear second order dynamic systems enables to expect that different objectives of treatment could be reached. We discuss the effect of different models of cancer growth (Gomperztian vs. logistic) and supporting vascular network growth. Moreover we analyze also sensitivity of controllability conditions with respect to delays in treatment actions.

Język oryginału	angielski
Tytuł publikacji goszczącej	Proceedings of the IASTED International Conference Modelling, Identification and Control, MIC 2015
Wydawca	Acta Press
Strony	110-116
Liczba stron	7
ISBN (elektroniczny)	9780889869752
Identyfikatory DOI	https://doi.org/10.2316/P.2015.826-017
Status publikacji	Opublikowano - 2015
Wydarzenie	2015 IASTED International Conference on Modelling, Identification and Control, MIC 2015 - Innsbruck, Austria Czas trwania: 16 lut 2015 → 17 lut 2015

Seria publikacji

Nazwa	Proceedings of the IASTED International Conference on Modelling, Identification and Control
ISSN (drukowany)	1025-8973

Konferencja

Konferencja	2015 IASTED International Conference on Modelling, Identification and Control, MIC 2015
Kraj/Terytorium	Austria
Miejscowość	Innsbruck
Okres	16/02/15 → 17/02/15

Cele SDG ONZ

Ten wynik przyczynia się do realizacji następujących celów zrównoważonego rozwoju

Cel 3 Dobre zdrowie i dobre samopoczucie

Obszary tematyczne ASJC Scopus

Oprogramowanie
Modelowanie i symulacja
Zastosowania informatyki

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10.2316/P.2015.826-017

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Cytowanie

Swierniak, A., & Klamka, J. (2015). Sensitivity of controllability conditions for models of combined anticancer therapy. W Proceedings of the IASTED International Conference Modelling, Identification and Control, MIC 2015 (str. 110-116). (Proceedings of the IASTED International Conference on Modelling, Identification and Control). Acta Press. https://doi.org/10.2316/P.2015.826-017

@inproceedings{847c2af68be54d79a1c0ba4d098b486c,

title = "Sensitivity of controllability conditions for models of combined anticancer therapy",

abstract = "We analyze sensitivity of sufficient conditions for local controllability for a class of models of treatment response to combined anticancer therapies. The combined therapy is understood as combination of direct anticancer strategy e.g. chemotherapy and indirect modality (in this case antiangiogenic therapy). Controllability of the models in the form of semilinear second order dynamic systems enables to expect that different objectives of treatment could be reached. We discuss the effect of different models of cancer growth (Gomperztian vs. logistic) and supporting vascular network growth. Moreover we analyze also sensitivity of controllability conditions with respect to delays in treatment actions.",

keywords = "Cancer modeling, Constrained controllability, Multimodal therapy, Semilinear systems",

author = "Andrzej Swierniak and Jerzy Klamka",

note = "Publisher Copyright: {\textcopyright} 2015, Acta Press. All rights reserved.; 2015 IASTED International Conference on Modelling, Identification and Control, MIC 2015 ; Conference date: 16-02-2015 Through 17-02-2015",

year = "2015",

doi = "10.2316/P.2015.826-017",

language = "English",

series = "Proceedings of the IASTED International Conference on Modelling, Identification and Control",

publisher = "Acta Press",

pages = "110--116",

booktitle = "Proceedings of the IASTED International Conference Modelling, Identification and Control, MIC 2015",

address = "Canada",

}

Swierniak, A & Klamka, J 2015, Sensitivity of controllability conditions for models of combined anticancer therapy. w Proceedings of the IASTED International Conference Modelling, Identification and Control, MIC 2015. Proceedings of the IASTED International Conference on Modelling, Identification and Control, Acta Press, str. 110-116, 2015 IASTED International Conference on Modelling, Identification and Control, MIC 2015, Innsbruck, Austria, 16/02/15. https://doi.org/10.2316/P.2015.826-017

Sensitivity of controllability conditions for models of combined anticancer therapy. / Swierniak, Andrzej; Klamka, Jerzy.
Proceedings of the IASTED International Conference Modelling, Identification and Control, MIC 2015. Acta Press, 2015. str. 110-116 (Proceedings of the IASTED International Conference on Modelling, Identification and Control).

Wyniki badań: Rozdział w książce/raport/materiał konferencyjny › Wkład w konferencję › recenzja

TY - GEN

T1 - Sensitivity of controllability conditions for models of combined anticancer therapy

AU - Swierniak, Andrzej

AU - Klamka, Jerzy

PY - 2015

Y1 - 2015

N2 - We analyze sensitivity of sufficient conditions for local controllability for a class of models of treatment response to combined anticancer therapies. The combined therapy is understood as combination of direct anticancer strategy e.g. chemotherapy and indirect modality (in this case antiangiogenic therapy). Controllability of the models in the form of semilinear second order dynamic systems enables to expect that different objectives of treatment could be reached. We discuss the effect of different models of cancer growth (Gomperztian vs. logistic) and supporting vascular network growth. Moreover we analyze also sensitivity of controllability conditions with respect to delays in treatment actions.

AB - We analyze sensitivity of sufficient conditions for local controllability for a class of models of treatment response to combined anticancer therapies. The combined therapy is understood as combination of direct anticancer strategy e.g. chemotherapy and indirect modality (in this case antiangiogenic therapy). Controllability of the models in the form of semilinear second order dynamic systems enables to expect that different objectives of treatment could be reached. We discuss the effect of different models of cancer growth (Gomperztian vs. logistic) and supporting vascular network growth. Moreover we analyze also sensitivity of controllability conditions with respect to delays in treatment actions.

KW - Cancer modeling

KW - Constrained controllability

KW - Multimodal therapy

KW - Semilinear systems

UR - https://www.scopus.com/pages/publications/85015741409

U2 - 10.2316/P.2015.826-017

DO - 10.2316/P.2015.826-017

M3 - Conference contribution

AN - SCOPUS:85015741409

T3 - Proceedings of the IASTED International Conference on Modelling, Identification and Control

SP - 110

EP - 116

BT - Proceedings of the IASTED International Conference Modelling, Identification and Control, MIC 2015

PB - Acta Press

T2 - 2015 IASTED International Conference on Modelling, Identification and Control, MIC 2015

Y2 - 16 February 2015 through 17 February 2015

ER -

Sensitivity of controllability conditions for models of combined anticancer therapy

Abstrakt

Seria publikacji

Konferencja

Cele SDG ONZ

Obszary tematyczne ASJC Scopus

Uzyskaj dostęp do dokumentu

Inne pliki i linki

Fingerprint

Cytowanie