Sensitivity analysis aimed at finding potential molecular drug targets

Jarosław Smieja; Małgorzata Kardyńska; Marta Pudlo

doi:10.14708/ma.v47i2.6488

Sensitivity analysis aimed at finding potential molecular drug targets

Przetłumaczony tytuł wkładu: Analiza wrażliwości ukierunkowana na poszukiwanie molekularnych celów dla leków

Katedra Inżynierii i Biologii Systemów (RAU/RAU1)

Silesian University of Technology

Wyniki badań: Wkład do czasopisma › Artykuł › recenzja

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Abstrakt

Sensitivity analysis has become one of the standard tools in analysis of models of intracellular processes. Various methods have been proposed, developed for either local or global sensitivity of systems under investigation. In this work, we propose a method that may be used to find potential molecular drug targets, taking into account heterogeneity of population of cells with respect to their responses to a particular drug agent.

Przetłumaczony tytuł wkładu	Analiza wrażliwości ukierunkowana na poszukiwanie molekularnych celów dla leków
Język oryginału	angielski
Strony (od–do)	197-205
Liczba stron	9
Czasopismo	Mathematica Applicanda
Tom	47
Numer wydania	2
Identyfikatory DOI	https://doi.org/10.14708/ma.v47i2.6488
Status publikacji	Opublikowano - 2019

Obszary tematyczne ASJC Scopus

Matematyka ogólna
Nauki o podejmowaniu decyzji (różne)

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10.14708/ma.v47i2.6488

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title = "Sensitivity analysis aimed at finding potential molecular drug targets",

abstract = "Sensitivity analysis has become one of the standard tools in analysis of models of intracellular processes. Various methods have been proposed, developed for either local or global sensitivity of systems under investigation. In this work, we propose a method that may be used to find potential molecular drug targets, taking into account heterogeneity of population of cells with respect to their responses to a particular drug agent.",

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AU - Smieja, Jarosław

AU - Kardyńska, Małgorzata

AU - Pudlo, Marta

PY - 2019

Y1 - 2019

N2 - Sensitivity analysis has become one of the standard tools in analysis of models of intracellular processes. Various methods have been proposed, developed for either local or global sensitivity of systems under investigation. In this work, we propose a method that may be used to find potential molecular drug targets, taking into account heterogeneity of population of cells with respect to their responses to a particular drug agent.

AB - Sensitivity analysis has become one of the standard tools in analysis of models of intracellular processes. Various methods have been proposed, developed for either local or global sensitivity of systems under investigation. In this work, we propose a method that may be used to find potential molecular drug targets, taking into account heterogeneity of population of cells with respect to their responses to a particular drug agent.

KW - Molecular drug targets

KW - Sensitivity analysis

KW - Signaling pathways

UR - https://www.scopus.com/pages/publications/85082326376

U2 - 10.14708/ma.v47i2.6488

DO - 10.14708/ma.v47i2.6488

M3 - Article

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Sensitivity analysis aimed at finding potential molecular drug targets

Abstrakt

Obszary tematyczne ASJC Scopus

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