Ratiometric pH-Responsive 19F Magnetic Resonance Imaging Contrast Agents Based on Hydrazone Switches

Dawid Janasik; Krzysztof Jasiński; Władysław P. Węglarz; Ivan Nemec; Pawel Jewula; Tomasz Krawczyk

doi:10.1021/acs.analchem.1c04978

Ratiometric pH-Responsive ¹⁹F Magnetic Resonance Imaging Contrast Agents Based on Hydrazone Switches

Dawid Janasik
, Krzysztof Jasiński
, Władysław P. Węglarz
, Ivan Nemec
, Pawel Jewula
, Tomasz Krawczyk

Institute of Nuclear Physics PAN
Central European Institute of Technology Brno University of Technology
Palacký University Olomouc

Wyniki badań: Wkład do czasopisma › Artykuł › recenzja

21 Cytowania z bazy Scopus

Abstrakt

Hydrazone-based molecular switches serve as efficient ratiometric pH-sensitive agents that can be tracked with ¹⁹F NMR/MRI and ¹H NMR. Structural changes induced between pH 3 and 4 lead to signal appearance and disappearance at ¹H and ¹⁹F NMR spectra allowing ratiometric pH measurements. The most pronounced are resonances of the CF₃ group shifted by 1.8 ppm with ¹⁹F NMR and a hydrazone proton shifted by 2 ppm with ¹H NMR.

Język oryginału	angielski
Strony (od–do)	3427-3431
Liczba stron	5
Czasopismo	Analytical Chemistry
Tom	94
Numer wydania	8
Identyfikatory DOI	https://doi.org/10.1021/acs.analchem.1c04978
Status publikacji	Opublikowano - 1 mar 2022

Obszary tematyczne ASJC Scopus

Chemia analityczna

Uzyskaj dostęp do dokumentu

10.1021/acs.analchem.1c04978

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Link do publikacji w Scopus

Cytowanie

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title = "Ratiometric pH-Responsive 19F Magnetic Resonance Imaging Contrast Agents Based on Hydrazone Switches",

abstract = "Hydrazone-based molecular switches serve as efficient ratiometric pH-sensitive agents that can be tracked with 19F NMR/MRI and 1H NMR. Structural changes induced between pH 3 and 4 lead to signal appearance and disappearance at 1H and 19F NMR spectra allowing ratiometric pH measurements. The most pronounced are resonances of the CF3 group shifted by 1.8 ppm with 19F NMR and a hydrazone proton shifted by 2 ppm with 1H NMR.",

author = "Dawid Janasik and Krzysztof Jasi{\'n}ski and W{\c e}glarz, \{W{\l}adys{\l}aw P.\} and Ivan Nemec and Pawel Jewula and Tomasz Krawczyk",

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year = "2022",

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doi = "10.1021/acs.analchem.1c04978",

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AU - Janasik, Dawid

AU - Jasiński, Krzysztof

AU - Węglarz, Władysław P.

AU - Nemec, Ivan

AU - Jewula, Pawel

AU - Krawczyk, Tomasz

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AB - Hydrazone-based molecular switches serve as efficient ratiometric pH-sensitive agents that can be tracked with 19F NMR/MRI and 1H NMR. Structural changes induced between pH 3 and 4 lead to signal appearance and disappearance at 1H and 19F NMR spectra allowing ratiometric pH measurements. The most pronounced are resonances of the CF3 group shifted by 1.8 ppm with 19F NMR and a hydrazone proton shifted by 2 ppm with 1H NMR.

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M3 - Article

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