TY - GEN
T1 - Protein comparison by the alignment of fuzzy energy signatures
AU - Mrozek, Dariusz
AU - Małysiak-Mrozek, Bozena
AU - Kozielski, Stanisław
PY - 2009
Y1 - 2009
N2 - Describing protein structures in terms of their energy features can be a key to understand how proteins work and interact to each other in cellular reactions. This can be also a base to compare proteins and search protein similarities. In the paper, we present protein comparison by the alignment of protein energy signatures. In the alignment, components of energy signatures are represented as fuzzy numbers. This modification increases the sensitivity of the alignment and guarantees the approximate character of the method, at the same time. The effectiveness of the developed alignment algorithm is tested by incorporating it in the new FS-EAST method (Fuzzy Signatures - Energy Alignment Search Tool), which allows to seek similar structural regions of proteins.
AB - Describing protein structures in terms of their energy features can be a key to understand how proteins work and interact to each other in cellular reactions. This can be also a base to compare proteins and search protein similarities. In the paper, we present protein comparison by the alignment of protein energy signatures. In the alignment, components of energy signatures are represented as fuzzy numbers. This modification increases the sensitivity of the alignment and guarantees the approximate character of the method, at the same time. The effectiveness of the developed alignment algorithm is tested by incorporating it in the new FS-EAST method (Fuzzy Signatures - Energy Alignment Search Tool), which allows to seek similar structural regions of proteins.
UR - https://www.scopus.com/pages/publications/69149105243
U2 - 10.1007/978-3-642-02962-2_36
DO - 10.1007/978-3-642-02962-2_36
M3 - Conference contribution
AN - SCOPUS:69149105243
SN - 3642029612
SN - 9783642029615
T3 - Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
SP - 289
EP - 296
BT - Rough Sets and Knowledge Technology - 4th International Conference, RSKT 2009, Proceedings
T2 - 4th International Conference on Rough Sets and Knowledge Technology, RSKT 2009
Y2 - 14 July 2009 through 16 July 2009
ER -