May Gender Have an Impact on Methylation Profile and Survival Prognosis in Acute Myeloid Leukemia?

Agnieszka Cecotka; Lukasz Krol; Grainne O’Brien; Christophe Badie; Joanna Polanska

doi:10.1007/978-3-030-86258-9_13

May Gender Have an Impact on Methylation Profile and Survival Prognosis in Acute Myeloid Leukemia?

Agnieszka Cecotka
, Lukasz Krol
, Grainne O’Brien
, Christophe Badie
, Joanna Polanska

Katedra Inżynierii i Analizy Eksploracyjnej Danych (RAU/RAU4)

Silesian University of Technology
UK Health Security Agency

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1 Cytowanie z bazy Scopus

Abstrakt

DNA methylation alteration is crucial for the initiation and development of Acute Myeloid Leukemia. However, only a few epigenetic biomarkers of AML have been discovered so far. DNA methylation of CpG rich gene promoters has the highest impact on gene expression level, so biomarkers should be sought in these genomic regions. Principal Component Analysis of methylation level reveals that male and female AML patients differ in CpG rich-gene promoters. Statistical comparison between males and females conducted for each CpG site confirms statistical relevance of differences only in CpG-rich promoter regions. P-value integration results in detection of AML-specific hypermethylated genomic regions and shows that almost 10% of CpG-rich promoters are differentially methylated between males and females. Functional analysis of genes with differentially methylated promoters in AML results in 322 enrichments for women and 1893 for men. Genes are mainly related to homeobox, cell development and morphogenesis. Survival analysis indentifies gender-specific potential epigenomic prognostic markers. Dissimilarity of the survival-significant gene sets between males and females is 75%.

Język oryginału	angielski
Tytuł publikacji goszczącej	Practical Applications of Computational Biology and Bioinformatics, 15th International Conference, PACBB 2021
Redaktorzy	Miguel Rocha, Florentino Fdez-Riverola, Mohd Saberi Mohamad, Roberto Casado-Vara
Wydawca	Springer Science and Business Media Deutschland GmbH
Strony	126-135
Liczba stron	10
ISBN (drukowany)	9783030862572
Identyfikatory DOI	https://doi.org/10.1007/978-3-030-86258-9_13
Status publikacji	Opublikowano - 2022
Wydarzenie	15th International Conference on Practical Applications of Computational Biology and Bioinformatics, PACBB 2021 - Salamanca, Hiszpania Czas trwania: 6 paź 2021 → 8 paź 2021

Seria publikacji

Nazwa	Lecture Notes in Networks and Systems
Tom	325 LNNS
ISSN (drukowany)	2367-3370
ISSN (elektroniczny)	2367-3389

Konferencja

Konferencja	15th International Conference on Practical Applications of Computational Biology and Bioinformatics, PACBB 2021
Kraj/Terytorium	Hiszpania
Miejscowość	Salamanca
Okres	6/10/21 → 8/10/21

Cele SDG ONZ

Ten wynik przyczynia się do realizacji następujących celów zrównoważonego rozwoju

Cel 3 Dobre zdrowie i dobre samopoczucie

Obszary tematyczne ASJC Scopus

Inżynieria sterowania i systemów
Przetwarzanie sygnałów
Sieci komputerowe i komunikacja

Uzyskaj dostęp do dokumentu

10.1007/978-3-030-86258-9_13

Inne pliki i linki

Link do publikacji w Scopus

Cytowanie

Cecotka, A., Krol, L., O’Brien, G., Badie, C., & Polanska, J. (2022). May Gender Have an Impact on Methylation Profile and Survival Prognosis in Acute Myeloid Leukemia? W M. Rocha, F. Fdez-Riverola, M. S. Mohamad, & R. Casado-Vara (Red.), Practical Applications of Computational Biology and Bioinformatics, 15th International Conference, PACBB 2021 (str. 126-135). (Lecture Notes in Networks and Systems; Tom 325 LNNS). Springer Science and Business Media Deutschland GmbH. https://doi.org/10.1007/978-3-030-86258-9_13

Cecotka, Agnieszka ; Krol, Lukasz ; O’Brien, Grainne i in. / May Gender Have an Impact on Methylation Profile and Survival Prognosis in Acute Myeloid Leukemia?. Practical Applications of Computational Biology and Bioinformatics, 15th International Conference, PACBB 2021. redaktor / Miguel Rocha ; Florentino Fdez-Riverola ; Mohd Saberi Mohamad ; Roberto Casado-Vara. Springer Science and Business Media Deutschland GmbH, 2022. str. 126-135 (Lecture Notes in Networks and Systems).

@inproceedings{7dc66ef9a6084e7796cbcae1718ca196,

title = "May Gender Have an Impact on Methylation Profile and Survival Prognosis in Acute Myeloid Leukemia?",

abstract = "DNA methylation alteration is crucial for the initiation and development of Acute Myeloid Leukemia. However, only a few epigenetic biomarkers of AML have been discovered so far. DNA methylation of CpG rich gene promoters has the highest impact on gene expression level, so biomarkers should be sought in these genomic regions. Principal Component Analysis of methylation level reveals that male and female AML patients differ in CpG rich-gene promoters. Statistical comparison between males and females conducted for each CpG site confirms statistical relevance of differences only in CpG-rich promoter regions. P-value integration results in detection of AML-specific hypermethylated genomic regions and shows that almost 10\% of CpG-rich promoters are differentially methylated between males and females. Functional analysis of genes with differentially methylated promoters in AML results in 322 enrichments for women and 1893 for men. Genes are mainly related to homeobox, cell development and morphogenesis. Survival analysis indentifies gender-specific potential epigenomic prognostic markers. Dissimilarity of the survival-significant gene sets between males and females is 75\%.",

keywords = "Acute Myeloid Leukaemia, DNA methylation, Epigenetics, Prognostic markers, Sex disparity, Survival analysis",

author = "Agnieszka Cecotka and Lukasz Krol and Grainne O{\textquoteright}Brien and Christophe Badie and Joanna Polanska",

note = "Publisher Copyright: {\textcopyright} 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG.; 15th International Conference on Practical Applications of Computational Biology and Bioinformatics, PACBB 2021 ; Conference date: 06-10-2021 Through 08-10-2021",

year = "2022",

doi = "10.1007/978-3-030-86258-9\_13",

language = "English",

isbn = "9783030862572",

series = "Lecture Notes in Networks and Systems",

publisher = "Springer Science and Business Media Deutschland GmbH",

pages = "126--135",

editor = "Miguel Rocha and Florentino Fdez-Riverola and Mohamad, \{Mohd Saberi\} and Roberto Casado-Vara",

booktitle = "Practical Applications of Computational Biology and Bioinformatics, 15th International Conference, PACBB 2021",

address = "Germany",

}

Cecotka, A, Krol, L, O’Brien, G, Badie, C & Polanska, J 2022, May Gender Have an Impact on Methylation Profile and Survival Prognosis in Acute Myeloid Leukemia? w M Rocha, F Fdez-Riverola, MS Mohamad & R Casado-Vara (red), Practical Applications of Computational Biology and Bioinformatics, 15th International Conference, PACBB 2021. Lecture Notes in Networks and Systems, tom 325 LNNS, Springer Science and Business Media Deutschland GmbH, str. 126-135, 15th International Conference on Practical Applications of Computational Biology and Bioinformatics, PACBB 2021, Salamanca, Hiszpania, 6/10/21. https://doi.org/10.1007/978-3-030-86258-9_13

May Gender Have an Impact on Methylation Profile and Survival Prognosis in Acute Myeloid Leukemia? / Cecotka, Agnieszka; Krol, Lukasz; O’Brien, Grainne i in.
Practical Applications of Computational Biology and Bioinformatics, 15th International Conference, PACBB 2021. red. / Miguel Rocha; Florentino Fdez-Riverola; Mohd Saberi Mohamad; Roberto Casado-Vara. Springer Science and Business Media Deutschland GmbH, 2022. str. 126-135 (Lecture Notes in Networks and Systems; Tom 325 LNNS).

Wyniki badań: Rozdział w książce/raport/materiał konferencyjny › Wkład w konferencję › recenzja