Controlling the intracellular processes

In this work we propose new approach to the cancer treatment. We postulate to consider cancer as a malfunction of the cells regulatory unit, and use control engineering and systems theory approaches to describe that malfunction. In our approach mathematical models were used for the description of system and its malfunction. Then we postulate to deliver a secondary control signal to the malfunctioning cells which role is to omit the damaged regions and return the cell to its normal parameters. This should results in a programmed death of the cancer cells. In this paper we introduce the cell as an object of control, describe p53 signaling pathway as an example of cellular regulatory unit, then discuss its possible malfunctions which result in cancer and describe available secondary control signals. Finally we present the results of our in silico experiments, which show the efficiency of the proposed secondary controls.