TY - GEN
T1 - Conditions for equivalence of stochastic and deterministic gene transcription models
AU - Smieja, Jaroslaw
PY - 2011
Y1 - 2011
N2 - The paper deals with two different approaches of modeling gene transcription in eukaryotic cells: stochastic and deterministic. The analysis is based on the assumption that dynamics of the transcription factor concentration is known from experimental work, first increasing and then decreasing, without oscillations. The expected value of transcription rate in a stochastic case is compared to deterministic transcription rate. Additionally, the dynamics of mRNA resulting from both models is analyzed. It appears that, despite claims in broad literature devoted to the topic, the deterministic description is a good approximation of an actual stochastic process.
AB - The paper deals with two different approaches of modeling gene transcription in eukaryotic cells: stochastic and deterministic. The analysis is based on the assumption that dynamics of the transcription factor concentration is known from experimental work, first increasing and then decreasing, without oscillations. The expected value of transcription rate in a stochastic case is compared to deterministic transcription rate. Additionally, the dynamics of mRNA resulting from both models is analyzed. It appears that, despite claims in broad literature devoted to the topic, the deterministic description is a good approximation of an actual stochastic process.
KW - Systems biology
KW - Transcription modeling
UR - https://www.scopus.com/pages/publications/79958157720
U2 - 10.2316/P.2011.723-065
DO - 10.2316/P.2011.723-065
M3 - Conference contribution
AN - SCOPUS:79958157720
SN - 9780889868663
T3 - Proceedings of the 8th IASTED International Conference on Biomedical Engineering, Biomed 2011
SP - 169
EP - 174
BT - Proceedings of the 8th IASTED International Conference on Biomedical Engineering, Biomed 2011
T2 - IASTED International Conference on Biomedical Engineering, Biomed 2011
Y2 - 16 February 2011 through 18 February 2011
ER -