TY - GEN
T1 - Application of adjoint sensitivity analysis to parameter estimation of age-structured model of cell cycle
AU - Jakubczak, Michał
AU - Fujarewicz, Krzysztof
N1 - Publisher Copyright:
© Springer International Publishing Switzerland 2016.
PY - 2016
Y1 - 2016
N2 - Age-structured models describe heterogeneous populations of individuals. Life of the individual consist of a finite number of phases, which differ in properties such as the ability to reproduce. This approach allows more realistic modelling of the population growth than using models assuming homogeneity of the population, which is especially important for complex organisms with long reproduction time. The aim of this study was to develop a methodology to estimate parameters of the age-structured model of cell cycle using adjoint sensitivity analysis. Results were obtained for artificially generated input data.
AB - Age-structured models describe heterogeneous populations of individuals. Life of the individual consist of a finite number of phases, which differ in properties such as the ability to reproduce. This approach allows more realistic modelling of the population growth than using models assuming homogeneity of the population, which is especially important for complex organisms with long reproduction time. The aim of this study was to develop a methodology to estimate parameters of the age-structured model of cell cycle using adjoint sensitivity analysis. Results were obtained for artificially generated input data.
KW - Adjoint sensitivity analysis
KW - Age-structured models
KW - Cell cycle
KW - Parameter estimation
UR - https://www.scopus.com/pages/publications/84976517826
U2 - 10.1007/978-3-319-39904-1_11
DO - 10.1007/978-3-319-39904-1_11
M3 - Conference contribution
AN - SCOPUS:84976517826
SN - 9783319399034
T3 - Advances in Intelligent Systems and Computing
SP - 123
EP - 131
BT - Information Technologies in Medicine - 5th International Conference, ITIB 2016, Proceedings
A2 - Piętka, Ewa
A2 - Badura, Pawel
A2 - Kawa, Jacek
A2 - Wieclawek, Wojciech
PB - Springer Verlag
T2 - 5th International Conference on Information Technologies in Biomedicine, ITIB 2016
Y2 - 20 June 2016 through 22 June 2016
ER -