Apoptotic regulatory module as switched control system analysis of asymptotic properties

Magdalena Ochab; Andrzej Swierniak; Jerzy Klamka; Krzysztof Puszynski

doi:10.5220/0006593601190126

Apoptotic regulatory module as switched control system analysis of asymptotic properties

Magdalena Ochab
, Andrzej Swierniak
, Jerzy Klamka
, Krzysztof Puszynski

Silesian University of Technology

Wyniki badań: Rozdział w książce/raport/materiał konferencyjny › Wkład w konferencję › recenzja

1 Cytowanie z bazy Scopus

Abstrakt

Switching control systems are getting increased interests due to their capability to exhibit simultaneously several kinds of dynamic behaviour in different parts of the system. Such hybrid systems can be applied in many different fields. We present the application of the switched control systems in modelling a biological system, precisely a p53-dependent apoptotic intercellular pathway. Biological experiments show that cells exhibit variety of different behaviours for the same external stimuli. Differences in cell responses lead to population split into fractions. We present the analysis of asymptotic properties of the apoptotic regulatory module with respect to a parameter which describes an effect of an external stress. Results show that the system can exhibit two types of behaviour: stabilization or oscillation near the equilibrium point.

Język oryginału	angielski
Tytuł publikacji goszczącej	BIOINFORMATICS 2018 - 9th International Conference on Bioinformatics Models, Methods and Algorithms, Proceedings; Part of 11th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2018
Redaktorzy	Paul Anderson, Hugo Gamboa, Ana Fred, Sergi Bermudez i Badia
Wydawca	SciTePress
Strony	119-126
Liczba stron	8
ISBN (elektroniczny)	9789897582806
Identyfikatory DOI	https://doi.org/10.5220/0006593601190126
Status publikacji	Opublikowano - 2018
Wydarzenie	9th International Conference on Bioinformatics Models, Methods and Algorithms, BIOINFORMATICS 2018 - Part of 11th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2018 - Funchal, Madeira, Portugalia Czas trwania: 19 sty 2018 → 21 sty 2018

Seria publikacji

Nazwa	BIOINFORMATICS 2018 - 9th International Conference on Bioinformatics Models, Methods and Algorithms, Proceedings; Part of 11th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2018
Tom	3

Konferencja

Konferencja	9th International Conference on Bioinformatics Models, Methods and Algorithms, BIOINFORMATICS 2018 - Part of 11th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2018
Kraj/Terytorium	Portugalia
Miejscowość	Funchal, Madeira
Okres	19/01/18 → 21/01/18

Obszary tematyczne ASJC Scopus

Inżynieria biomedyczna
Inżynieria elektryczna i elektroniczna
Informatyka medyczna

Uzyskaj dostęp do dokumentu

10.5220/0006593601190126

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Link do publikacji w Scopus

Cytowanie

Ochab, M., Swierniak, A., Klamka, J., & Puszynski, K. (2018). Apoptotic regulatory module as switched control system analysis of asymptotic properties. W P. Anderson, H. Gamboa, A. Fred, & S. Bermudez i Badia (Red.), BIOINFORMATICS 2018 - 9th International Conference on Bioinformatics Models, Methods and Algorithms, Proceedings; Part of 11th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2018 (str. 119-126). (BIOINFORMATICS 2018 - 9th International Conference on Bioinformatics Models, Methods and Algorithms, Proceedings; Part of 11th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2018; Tom 3). SciTePress. https://doi.org/10.5220/0006593601190126

Ochab, Magdalena ; Swierniak, Andrzej ; Klamka, Jerzy i in. / Apoptotic regulatory module as switched control system analysis of asymptotic properties. BIOINFORMATICS 2018 - 9th International Conference on Bioinformatics Models, Methods and Algorithms, Proceedings; Part of 11th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2018. redaktor / Paul Anderson ; Hugo Gamboa ; Ana Fred ; Sergi Bermudez i Badia. SciTePress, 2018. str. 119-126 (BIOINFORMATICS 2018 - 9th International Conference on Bioinformatics Models, Methods and Algorithms, Proceedings; Part of 11th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2018).

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title = "Apoptotic regulatory module as switched control system analysis of asymptotic properties",

abstract = "Switching control systems are getting increased interests due to their capability to exhibit simultaneously several kinds of dynamic behaviour in different parts of the system. Such hybrid systems can be applied in many different fields. We present the application of the switched control systems in modelling a biological system, precisely a p53-dependent apoptotic intercellular pathway. Biological experiments show that cells exhibit variety of different behaviours for the same external stimuli. Differences in cell responses lead to population split into fractions. We present the analysis of asymptotic properties of the apoptotic regulatory module with respect to a parameter which describes an effect of an external stress. Results show that the system can exhibit two types of behaviour: stabilization or oscillation near the equilibrium point.",

keywords = "Biological System, Piece-wise Linear Model, Switchings",

author = "Magdalena Ochab and Andrzej Swierniak and Jerzy Klamka and Krzysztof Puszynski",

note = "Publisher Copyright: Copyright {\textcopyright} 2018 by SCITEPRESS {\textendash} Science and Technology Publications, Lda. All rights reserved; 9th International Conference on Bioinformatics Models, Methods and Algorithms, BIOINFORMATICS 2018 - Part of 11th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2018 ; Conference date: 19-01-2018 Through 21-01-2018",

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doi = "10.5220/0006593601190126",

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pages = "119--126",

editor = "Paul Anderson and Hugo Gamboa and Ana Fred and \{Bermudez i Badia\}, Sergi",

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Ochab, M, Swierniak, A, Klamka, J & Puszynski, K 2018, Apoptotic regulatory module as switched control system analysis of asymptotic properties. w P Anderson, H Gamboa, A Fred & S Bermudez i Badia (red), BIOINFORMATICS 2018 - 9th International Conference on Bioinformatics Models, Methods and Algorithms, Proceedings; Part of 11th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2018. BIOINFORMATICS 2018 - 9th International Conference on Bioinformatics Models, Methods and Algorithms, Proceedings; Part of 11th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2018, tom 3, SciTePress, str. 119-126, 9th International Conference on Bioinformatics Models, Methods and Algorithms, BIOINFORMATICS 2018 - Part of 11th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2018, Funchal, Madeira, Portugalia, 19/01/18. https://doi.org/10.5220/0006593601190126

Apoptotic regulatory module as switched control system analysis of asymptotic properties. / Ochab, Magdalena; Swierniak, Andrzej; Klamka, Jerzy i in.
BIOINFORMATICS 2018 - 9th International Conference on Bioinformatics Models, Methods and Algorithms, Proceedings; Part of 11th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2018. red. / Paul Anderson; Hugo Gamboa; Ana Fred; Sergi Bermudez i Badia. SciTePress, 2018. str. 119-126 (BIOINFORMATICS 2018 - 9th International Conference on Bioinformatics Models, Methods and Algorithms, Proceedings; Part of 11th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2018; Tom 3).

Wyniki badań: Rozdział w książce/raport/materiał konferencyjny › Wkład w konferencję › recenzja

TY - GEN

T1 - Apoptotic regulatory module as switched control system analysis of asymptotic properties

AU - Ochab, Magdalena

AU - Swierniak, Andrzej

AU - Klamka, Jerzy

AU - Puszynski, Krzysztof

PY - 2018

Y1 - 2018

N2 - Switching control systems are getting increased interests due to their capability to exhibit simultaneously several kinds of dynamic behaviour in different parts of the system. Such hybrid systems can be applied in many different fields. We present the application of the switched control systems in modelling a biological system, precisely a p53-dependent apoptotic intercellular pathway. Biological experiments show that cells exhibit variety of different behaviours for the same external stimuli. Differences in cell responses lead to population split into fractions. We present the analysis of asymptotic properties of the apoptotic regulatory module with respect to a parameter which describes an effect of an external stress. Results show that the system can exhibit two types of behaviour: stabilization or oscillation near the equilibrium point.

AB - Switching control systems are getting increased interests due to their capability to exhibit simultaneously several kinds of dynamic behaviour in different parts of the system. Such hybrid systems can be applied in many different fields. We present the application of the switched control systems in modelling a biological system, precisely a p53-dependent apoptotic intercellular pathway. Biological experiments show that cells exhibit variety of different behaviours for the same external stimuli. Differences in cell responses lead to population split into fractions. We present the analysis of asymptotic properties of the apoptotic regulatory module with respect to a parameter which describes an effect of an external stress. Results show that the system can exhibit two types of behaviour: stabilization or oscillation near the equilibrium point.

KW - Biological System

KW - Piece-wise Linear Model

KW - Switchings

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DO - 10.5220/0006593601190126

M3 - Conference contribution

AN - SCOPUS:85051713418

T3 - BIOINFORMATICS 2018 - 9th International Conference on Bioinformatics Models, Methods and Algorithms, Proceedings; Part of 11th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2018

SP - 119

EP - 126

BT - BIOINFORMATICS 2018 - 9th International Conference on Bioinformatics Models, Methods and Algorithms, Proceedings; Part of 11th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2018

A2 - Anderson, Paul

A2 - Gamboa, Hugo

A2 - Fred, Ana

A2 - Bermudez i Badia, Sergi

PB - SciTePress

T2 - 9th International Conference on Bioinformatics Models, Methods and Algorithms, BIOINFORMATICS 2018 - Part of 11th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2018

Y2 - 19 January 2018 through 21 January 2018

ER -

Ochab M, Swierniak A, Klamka J, Puszynski K. Apoptotic regulatory module as switched control system analysis of asymptotic properties. W Anderson P, Gamboa H, Fred A, Bermudez i Badia S, redaktorzy, BIOINFORMATICS 2018 - 9th International Conference on Bioinformatics Models, Methods and Algorithms, Proceedings; Part of 11th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2018. SciTePress. 2018. str. 119-126. (BIOINFORMATICS 2018 - 9th International Conference on Bioinformatics Models, Methods and Algorithms, Proceedings; Part of 11th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2018). doi: 10.5220/0006593601190126

Apoptotic regulatory module as switched control system analysis of asymptotic properties

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Obszary tematyczne ASJC Scopus

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