Three-compartmental model of a cell cycle and drug resistance in chemotherapy design

A. Swierniak; J. Smieja

Three-compartmental model of a cell cycle and drug resistance in chemotherapy design

Department of Systems Biology and Engineering (RAU/RAU1)

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

This paper presents an approach to modelling of the cancer cell population that takes into account phase-specific chemotherapy and evolution of drug resistance stemming from gene amplification. It allows to analyse simultaneously these two aspects of chemotherapy that have been studied separately so far. The mathematical model is based on three compartments in the cell cycle and two drugs that are administered in different phases: a blocking and a killing agent. The task of finding the best chemotherapy protocol is given by an optimal control problem defined in l¹ space, which aims at killing the greatest number of cancer cells while simultaneously trying to minimise side effects of the drugs.

Original language	English
Title of host publication	Proceedings of the IASTED International Conference on Biomedical Engineering
Editors	M.H. Hamza
Pages	71-76
Number of pages	6
Publication status	Published - 2003
Event	Proceedings of the IASTED International Conference on Biomedical Engineering - Salzburg, Austria Duration: 25 Jun 2003 → 27 Jun 2003

Publication series

Name	Proceedings of the IASTED International Conference on Biomedical Engineering

Conference

Conference	Proceedings of the IASTED International Conference on Biomedical Engineering
Country/Territory	Austria
City	Salzburg
Period	25/06/03 → 27/06/03

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Biomedical modelling
Drug resistance
Phase-specific chemotherapy

ASJC Scopus subject areas

General Engineering

Cite this

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title = "Three-compartmental model of a cell cycle and drug resistance in chemotherapy design",

abstract = "This paper presents an approach to modelling of the cancer cell population that takes into account phase-specific chemotherapy and evolution of drug resistance stemming from gene amplification. It allows to analyse simultaneously these two aspects of chemotherapy that have been studied separately so far. The mathematical model is based on three compartments in the cell cycle and two drugs that are administered in different phases: a blocking and a killing agent. The task of finding the best chemotherapy protocol is given by an optimal control problem defined in l1 space, which aims at killing the greatest number of cancer cells while simultaneously trying to minimise side effects of the drugs.",

keywords = "Biomedical modelling, Drug resistance, Phase-specific chemotherapy",

author = "A. Swierniak and J. Smieja",

year = "2003",

language = "English",

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series = "Proceedings of the IASTED International Conference on Biomedical Engineering",

pages = "71--76",

editor = "M.H. Hamza",

booktitle = "Proceedings of the IASTED International Conference on Biomedical Engineering",

note = "Proceedings of the IASTED International Conference on Biomedical Engineering ; Conference date: 25-06-2003 Through 27-06-2003",

}

Swierniak, A & Smieja, J 2003, Three-compartmental model of a cell cycle and drug resistance in chemotherapy design. in MH Hamza (ed.), Proceedings of the IASTED International Conference on Biomedical Engineering. Proceedings of the IASTED International Conference on Biomedical Engineering, pp. 71-76, Proceedings of the IASTED International Conference on Biomedical Engineering, Salzburg, Austria, 25/06/03.

Three-compartmental model of a cell cycle and drug resistance in chemotherapy design. / Swierniak, A.; Smieja, J.
Proceedings of the IASTED International Conference on Biomedical Engineering. ed. / M.H. Hamza. 2003. p. 71-76 (Proceedings of the IASTED International Conference on Biomedical Engineering).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Three-compartmental model of a cell cycle and drug resistance in chemotherapy design

AU - Swierniak, A.

AU - Smieja, J.

PY - 2003

Y1 - 2003

N2 - This paper presents an approach to modelling of the cancer cell population that takes into account phase-specific chemotherapy and evolution of drug resistance stemming from gene amplification. It allows to analyse simultaneously these two aspects of chemotherapy that have been studied separately so far. The mathematical model is based on three compartments in the cell cycle and two drugs that are administered in different phases: a blocking and a killing agent. The task of finding the best chemotherapy protocol is given by an optimal control problem defined in l1 space, which aims at killing the greatest number of cancer cells while simultaneously trying to minimise side effects of the drugs.

AB - This paper presents an approach to modelling of the cancer cell population that takes into account phase-specific chemotherapy and evolution of drug resistance stemming from gene amplification. It allows to analyse simultaneously these two aspects of chemotherapy that have been studied separately so far. The mathematical model is based on three compartments in the cell cycle and two drugs that are administered in different phases: a blocking and a killing agent. The task of finding the best chemotherapy protocol is given by an optimal control problem defined in l1 space, which aims at killing the greatest number of cancer cells while simultaneously trying to minimise side effects of the drugs.

KW - Biomedical modelling

KW - Drug resistance

KW - Phase-specific chemotherapy

UR - https://www.scopus.com/pages/publications/2642518164

M3 - Conference contribution

AN - SCOPUS:2642518164

SN - 0889863539

T3 - Proceedings of the IASTED International Conference on Biomedical Engineering

SP - 71

EP - 76

BT - Proceedings of the IASTED International Conference on Biomedical Engineering

A2 - Hamza, M.H.

T2 - Proceedings of the IASTED International Conference on Biomedical Engineering

Y2 - 25 June 2003 through 27 June 2003

ER -

Three-compartmental model of a cell cycle and drug resistance in chemotherapy design

Abstract

Publication series

Conference

UN SDGs

Keywords

ASJC Scopus subject areas

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