Abstract
Synthesis, antiproliferative activity and the X-ray single-crystal structure of the 3-benzylthio-4-propargylselenoquinoline are described. The title compound belongs to the group of the acetylenic derivatives of thioquinolines, which have been intensively investigated as a source of new anticancer agents. The comparative study regarding the X-ray structure, the molecular electrostatic potential analysis, and structure-activity relationship for the title compound and the 3-methylthio-4-propargylthioquinoline and 3-methylthio-4-propargylselenoquinoline are presented.
| Original language | English |
|---|---|
| Pages (from-to) | 551-564 |
| Number of pages | 14 |
| Journal | Medicinal Chemistry Research |
| Volume | 19 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Jul 2010 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Antiproliferative activity
- Electrostatic potential
- Structure-activity relationship
ASJC Scopus subject areas
- General Pharmacology, Toxicology and Pharmaceutics
- Organic Chemistry
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