Synthesis of 2,4-diaminoquinazoline derivatives

Wojciech Zieliński; Agnieszka Kudelko; Elizabeth M. Holt

doi:10.3987/COM-97-8038

Synthesis of 2,4-diaminoquinazoline derivatives

Wojciech Zieliński
, Agnieszka Kudelko
, Elizabeth M. Holt

Department of Chemical Organic Technology and Petrochemistry (RCH/RCH5)

Silesian University of Technology
Oklahoma State University

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

A series of 6- and 7-substituted derivatives of 2-(N,N-diethylamino)-4-(N,N-dimethylamino)quinazoline have been synthesized. The synthesis consists in converting N-phenyl-N',N'-diethylurea into chloroamidines which are treated with N,N-dimethylcyanamide to 1-chloro-2,4-diaza-1,3-butadiene derivatives, followed by a cyclization to quinazoline derivatives.

Original language	English
Pages (from-to)	319-328
Number of pages	10
Journal	Heterocycles
Volume	48
Issue number	2
DOIs	https://doi.org/10.3987/COM-97-8038
Publication status	Published - 1998

ASJC Scopus subject areas

Analytical Chemistry
Pharmacology
Organic Chemistry

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title = "Synthesis of 2,4-diaminoquinazoline derivatives",

abstract = "A series of 6- and 7-substituted derivatives of 2-(N,N-diethylamino)-4-(N,N-dimethylamino)quinazoline have been synthesized. The synthesis consists in converting N-phenyl-N',N'-diethylurea into chloroamidines which are treated with N,N-dimethylcyanamide to 1-chloro-2,4-diaza-1,3-butadiene derivatives, followed by a cyclization to quinazoline derivatives.",

author = "Wojciech Zieli{\'n}ski and Agnieszka Kudelko and Holt, \{Elizabeth M.\}",

year = "1998",

doi = "10.3987/COM-97-8038",

language = "English",

volume = "48",

pages = "319--328",

journal = "Heterocycles",

issn = "0385-5414",

publisher = "Japan Institute of Heterocyclic Chemistry",

number = "2",

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TY - JOUR

T1 - Synthesis of 2,4-diaminoquinazoline derivatives

AU - Zieliński, Wojciech

AU - Kudelko, Agnieszka

AU - Holt, Elizabeth M.

PY - 1998

Y1 - 1998

N2 - A series of 6- and 7-substituted derivatives of 2-(N,N-diethylamino)-4-(N,N-dimethylamino)quinazoline have been synthesized. The synthesis consists in converting N-phenyl-N',N'-diethylurea into chloroamidines which are treated with N,N-dimethylcyanamide to 1-chloro-2,4-diaza-1,3-butadiene derivatives, followed by a cyclization to quinazoline derivatives.

AB - A series of 6- and 7-substituted derivatives of 2-(N,N-diethylamino)-4-(N,N-dimethylamino)quinazoline have been synthesized. The synthesis consists in converting N-phenyl-N',N'-diethylurea into chloroamidines which are treated with N,N-dimethylcyanamide to 1-chloro-2,4-diaza-1,3-butadiene derivatives, followed by a cyclization to quinazoline derivatives.

UR - https://www.scopus.com/pages/publications/0012788792

U2 - 10.3987/COM-97-8038

DO - 10.3987/COM-97-8038

M3 - Article

AN - SCOPUS:0012788792

SN - 0385-5414

VL - 48

SP - 319

EP - 328

JO - Heterocycles

JF - Heterocycles

IS - 2

ER -

Synthesis of 2,4-diaminoquinazoline derivatives

Abstract

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