Synthesis of 2-deoxy-hexopyranosyl derivatives of uridine as donor substrate analogues for glycosyltransferases

Ilona Wandzik; Tadeusz Bieg; Marianna Czaplicka

doi:10.1016/j.bioorg.2009.08.001

Synthesis of 2-deoxy-hexopyranosyl derivatives of uridine as donor substrate analogues for glycosyltransferases

Ilona Wandzik
, Tadeusz Bieg
, Marianna Czaplicka

Department of Organic Chemistry; Bioorganic Chemistry and Biotechnology (RCH/RCH2)

Institute of Non-Ferrous Metals

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

A series of 2-deoxy-hexopyranosyl derivatives of uridine have been synthesized as analogues of UDP-sugar. These compounds were tested as inhibitors against bovine β-1,4-galactosyltransferase I in fluorescent assays and showed no significant inhibition.

Original language	English
Pages (from-to)	211-216
Number of pages	6
Journal	Bioorganic Chemistry
Volume	37
Issue number	6
DOIs	https://doi.org/10.1016/j.bioorg.2009.08.001
Publication status	Published - Dec 2009

Keywords

Donor substrate analogues
Glycals
Glycosyltransferases

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Drug Discovery
Organic Chemistry

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10.1016/j.bioorg.2009.08.001

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title = "Synthesis of 2-deoxy-hexopyranosyl derivatives of uridine as donor substrate analogues for glycosyltransferases",

abstract = "A series of 2-deoxy-hexopyranosyl derivatives of uridine have been synthesized as analogues of UDP-sugar. These compounds were tested as inhibitors against bovine β-1,4-galactosyltransferase I in fluorescent assays and showed no significant inhibition.",

keywords = "Donor substrate analogues, Glycals, Glycosyltransferases",

author = "Ilona Wandzik and Tadeusz Bieg and Marianna Czaplicka",

year = "2009",

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doi = "10.1016/j.bioorg.2009.08.001",

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volume = "37",

pages = "211--216",

journal = "Bioorganic Chemistry",

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T1 - Synthesis of 2-deoxy-hexopyranosyl derivatives of uridine as donor substrate analogues for glycosyltransferases

AU - Wandzik, Ilona

AU - Bieg, Tadeusz

AU - Czaplicka, Marianna

PY - 2009/12

Y1 - 2009/12

N2 - A series of 2-deoxy-hexopyranosyl derivatives of uridine have been synthesized as analogues of UDP-sugar. These compounds were tested as inhibitors against bovine β-1,4-galactosyltransferase I in fluorescent assays and showed no significant inhibition.

AB - A series of 2-deoxy-hexopyranosyl derivatives of uridine have been synthesized as analogues of UDP-sugar. These compounds were tested as inhibitors against bovine β-1,4-galactosyltransferase I in fluorescent assays and showed no significant inhibition.

KW - Donor substrate analogues

KW - Glycals

KW - Glycosyltransferases

UR - https://www.scopus.com/pages/publications/70350780185

U2 - 10.1016/j.bioorg.2009.08.001

DO - 10.1016/j.bioorg.2009.08.001

M3 - Article

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AN - SCOPUS:70350780185

SN - 0045-2068

VL - 37

SP - 211

EP - 216

JO - Bioorganic Chemistry

JF - Bioorganic Chemistry

IS - 6

ER -

Synthesis of 2-deoxy-hexopyranosyl derivatives of uridine as donor substrate analogues for glycosyltransferases

Abstract

Keywords

ASJC Scopus subject areas

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