@inproceedings{0b0d380ec1f6480f9900e3231a89ba0d,
title = "Simulation methods in uncovering new regulatory mechanisms in signaling pathways",
abstract = "The paper deals with in silico investigation of possible regulatory mechanisms involved in control of signaling pathways. As an example, the Interferon- b activated pathway has been chosen. Though many processes involved in this pathway are known, there are still some that evade explanation. One of them is the nuclear accumulation of the IRF1 protein. Here, three hypotheses are stated and tested numerically, showing that the most likely mechanism involved in this process is an inhibition of IRF1 activation by an yet unrecognized factor.",
keywords = "IRF1, Interferon-{\ss}, Signaling pathways",
author = "Jaroslaw Smieja",
year = "2009",
doi = "10.1007/978-3-642-00727-9\_37",
language = "English",
isbn = "3642007260",
series = "Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)",
pages = "400--408",
booktitle = "Bioinformatics and Computational Biology - First International Conference, BICoB 2009, Proceedings",
note = "1st International Conference on Bioinformatics and Computational Biology, BICoB 2009 ; Conference date: 08-04-2009 Through 10-04-2009",
}