Photoacoustic detection of drug diffusion into a membrane: Theory and numerical analysis

Jerzy Bodzenta; Roman J. Bukowski; Andreas Christ; Tomasz Pogoda

doi:10.1016/S0017-9310(02)00155-2

Photoacoustic detection of drug diffusion into a membrane: Theory and numerical analysis

Jerzy Bodzenta
, Roman J. Bukowski
, Andreas Christ
, Tomasz Pogoda

Division of Applied Physics (RIF/RIF3)

Silesian University of Technology
Martin Luther University Halle-Wittenberg

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Possibility of the analysis of drug penetration through membranes using photoacoustic effect is considered. Based on Fick's second law the problem of the spatial and time dependent distribution of drugs in membranes is solved. The solution allows to derive the distribution of heat sources arising in the membrane from intensity modulated light illumination. Subsequently the temperature of the illuminated membrane surface is analysed numerically. This temperature is directly correlated to the signal registered in photoacoustic measurements. The influence of different parameters of the theoretical model on the ac component of the temperature of illuminated membrane surface has been analysed. Conclusions about possibilities and limitations of the considered method are discussed.

Original language	English
Pages (from-to)	4515-4523
Number of pages	9
Journal	International Journal of Heat and Mass Transfer
Volume	45
Issue number	22
DOIs	https://doi.org/10.1016/S0017-9310(02)00155-2
Publication status	Published - Oct 2002

ASJC Scopus subject areas

Condensed Matter Physics
Mechanical Engineering
Fluid Flow and Transfer Processes

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10.1016/S0017-9310(02)00155-2

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title = "Photoacoustic detection of drug diffusion into a membrane: Theory and numerical analysis",

abstract = "Possibility of the analysis of drug penetration through membranes using photoacoustic effect is considered. Based on Fick's second law the problem of the spatial and time dependent distribution of drugs in membranes is solved. The solution allows to derive the distribution of heat sources arising in the membrane from intensity modulated light illumination. Subsequently the temperature of the illuminated membrane surface is analysed numerically. This temperature is directly correlated to the signal registered in photoacoustic measurements. The influence of different parameters of the theoretical model on the ac component of the temperature of illuminated membrane surface has been analysed. Conclusions about possibilities and limitations of the considered method are discussed.",

author = "Jerzy Bodzenta and Bukowski, \{Roman J.\} and Andreas Christ and Tomasz Pogoda",

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T2 - Theory and numerical analysis

AU - Bodzenta, Jerzy

AU - Bukowski, Roman J.

AU - Christ, Andreas

AU - Pogoda, Tomasz

PY - 2002/10

Y1 - 2002/10

N2 - Possibility of the analysis of drug penetration through membranes using photoacoustic effect is considered. Based on Fick's second law the problem of the spatial and time dependent distribution of drugs in membranes is solved. The solution allows to derive the distribution of heat sources arising in the membrane from intensity modulated light illumination. Subsequently the temperature of the illuminated membrane surface is analysed numerically. This temperature is directly correlated to the signal registered in photoacoustic measurements. The influence of different parameters of the theoretical model on the ac component of the temperature of illuminated membrane surface has been analysed. Conclusions about possibilities and limitations of the considered method are discussed.

AB - Possibility of the analysis of drug penetration through membranes using photoacoustic effect is considered. Based on Fick's second law the problem of the spatial and time dependent distribution of drugs in membranes is solved. The solution allows to derive the distribution of heat sources arising in the membrane from intensity modulated light illumination. Subsequently the temperature of the illuminated membrane surface is analysed numerically. This temperature is directly correlated to the signal registered in photoacoustic measurements. The influence of different parameters of the theoretical model on the ac component of the temperature of illuminated membrane surface has been analysed. Conclusions about possibilities and limitations of the considered method are discussed.

UR - https://www.scopus.com/pages/publications/0036780777

U2 - 10.1016/S0017-9310(02)00155-2

DO - 10.1016/S0017-9310(02)00155-2

M3 - Article

AN - SCOPUS:0036780777

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JO - International Journal of Heat and Mass Transfer

JF - International Journal of Heat and Mass Transfer

IS - 22

ER -

Photoacoustic detection of drug diffusion into a membrane: Theory and numerical analysis

Abstract

ASJC Scopus subject areas

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