Optimization of antiangiogenic therapy as optimal control problem

Andrzej Swierniak; Grzegorz Gala; Alberto Gandolfi; Alberto D'Onofrio

Optimization of antiangiogenic therapy as optimal control problem

Andrzej Swierniak
, Grzegorz Gala
, Alberto Gandolfi
, Alberto D'Onofrio

Department of Systems Biology and Engineering (RAU/RAU1)

Maria Sklodowska-Curie Institute of Oncology
Istituto di Analisi dei Sistemi ed Informatica
IRCCS Istituto Europeo di Oncologia - Milano

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

27 Citations (Scopus)

Abstract

A model of antiangiogenic cancer chemotherapy is proposed and analyzed. The model is a modified Hahnfeldt model and the analysis has two goals: first of all we check stability of the equilibrium point of the model to find conditions leading to tumour eradication then we propose an optimization problem and give necessary conditions of its solution.

Original language	English
Title of host publication	Proceedings of the Fourth IASTED International Conference on Biomechanics, BioMech 2006
Pages	56-59
Number of pages	4
Publication status	Published - 2006
Event	4th IASTED International Conference on Biomechanics, BioMech 2006 - Palma de Mallorca, Spain Duration: 28 Aug 2006 → 29 Aug 2006

Publication series

Name	Proceedings of the Fourth IASTED International Conference on Biomechanics, BioMech 2006

Conference

Conference	4th IASTED International Conference on Biomechanics, BioMech 2006
Country/Territory	Spain
City	Palma de Mallorca
Period	28/08/06 → 29/08/06

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Angiogenesis
Anticancer therapy
Drug delivery
Modeling
Simulation
Systems and control

ASJC Scopus subject areas

Biophysics
Mechanical Engineering

Cite this

@inproceedings{7b47c010bd9e48f0a88a8455fc104d41,

title = "Optimization of antiangiogenic therapy as optimal control problem",

abstract = "A model of antiangiogenic cancer chemotherapy is proposed and analyzed. The model is a modified Hahnfeldt model and the analysis has two goals: first of all we check stability of the equilibrium point of the model to find conditions leading to tumour eradication then we propose an optimization problem and give necessary conditions of its solution.",

keywords = "Angiogenesis, Anticancer therapy, Drug delivery, Modeling, Simulation, Systems and control",

author = "Andrzej Swierniak and Grzegorz Gala and Alberto Gandolfi and Alberto D'Onofrio",

year = "2006",

language = "English",

isbn = "9780889866041",

series = "Proceedings of the Fourth IASTED International Conference on Biomechanics, BioMech 2006",

pages = "56--59",

booktitle = "Proceedings of the Fourth IASTED International Conference on Biomechanics, BioMech 2006",

note = "4th IASTED International Conference on Biomechanics, BioMech 2006 ; Conference date: 28-08-2006 Through 29-08-2006",

}

Swierniak, A, Gala, G, Gandolfi, A & D'Onofrio, A 2006, Optimization of antiangiogenic therapy as optimal control problem. in Proceedings of the Fourth IASTED International Conference on Biomechanics, BioMech 2006. Proceedings of the Fourth IASTED International Conference on Biomechanics, BioMech 2006, pp. 56-59, 4th IASTED International Conference on Biomechanics, BioMech 2006, Palma de Mallorca, Spain, 28/08/06.

Optimization of antiangiogenic therapy as optimal control problem. / Swierniak, Andrzej; Gala, Grzegorz; Gandolfi, Alberto et al.
Proceedings of the Fourth IASTED International Conference on Biomechanics, BioMech 2006. 2006. p. 56-59 (Proceedings of the Fourth IASTED International Conference on Biomechanics, BioMech 2006).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Optimization of antiangiogenic therapy as optimal control problem

AU - Swierniak, Andrzej

AU - Gala, Grzegorz

AU - Gandolfi, Alberto

AU - D'Onofrio, Alberto

PY - 2006

Y1 - 2006

N2 - A model of antiangiogenic cancer chemotherapy is proposed and analyzed. The model is a modified Hahnfeldt model and the analysis has two goals: first of all we check stability of the equilibrium point of the model to find conditions leading to tumour eradication then we propose an optimization problem and give necessary conditions of its solution.

AB - A model of antiangiogenic cancer chemotherapy is proposed and analyzed. The model is a modified Hahnfeldt model and the analysis has two goals: first of all we check stability of the equilibrium point of the model to find conditions leading to tumour eradication then we propose an optimization problem and give necessary conditions of its solution.

KW - Angiogenesis

KW - Anticancer therapy

KW - Drug delivery

KW - Modeling

KW - Simulation

KW - Systems and control

UR - https://www.scopus.com/pages/publications/38349139013

M3 - Conference contribution

AN - SCOPUS:38349139013

SN - 9780889866041

T3 - Proceedings of the Fourth IASTED International Conference on Biomechanics, BioMech 2006

SP - 56

EP - 59

BT - Proceedings of the Fourth IASTED International Conference on Biomechanics, BioMech 2006

T2 - 4th IASTED International Conference on Biomechanics, BioMech 2006

Y2 - 28 August 2006 through 29 August 2006

ER -

Optimization of antiangiogenic therapy as optimal control problem

Abstract

Publication series

Conference

UN SDGs

Keywords

ASJC Scopus subject areas

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