May Gender Have an Impact on Methylation Profile and Survival Prognosis in Acute Myeloid Leukemia?

Agnieszka Cecotka; Lukasz Krol; Grainne O’Brien; Christophe Badie; Joanna Polanska

doi:10.1007/978-3-030-86258-9_13

May Gender Have an Impact on Methylation Profile and Survival Prognosis in Acute Myeloid Leukemia?

Agnieszka Cecotka
, Lukasz Krol
, Grainne O’Brien
, Christophe Badie
, Joanna Polanska

Department of Data Science and Engineering (RAU/RAU4)

Silesian University of Technology
UK Health Security Agency

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

1 Citation (Scopus)

Abstract

DNA methylation alteration is crucial for the initiation and development of Acute Myeloid Leukemia. However, only a few epigenetic biomarkers of AML have been discovered so far. DNA methylation of CpG rich gene promoters has the highest impact on gene expression level, so biomarkers should be sought in these genomic regions. Principal Component Analysis of methylation level reveals that male and female AML patients differ in CpG rich-gene promoters. Statistical comparison between males and females conducted for each CpG site confirms statistical relevance of differences only in CpG-rich promoter regions. P-value integration results in detection of AML-specific hypermethylated genomic regions and shows that almost 10% of CpG-rich promoters are differentially methylated between males and females. Functional analysis of genes with differentially methylated promoters in AML results in 322 enrichments for women and 1893 for men. Genes are mainly related to homeobox, cell development and morphogenesis. Survival analysis indentifies gender-specific potential epigenomic prognostic markers. Dissimilarity of the survival-significant gene sets between males and females is 75%.

Original language	English
Title of host publication	Practical Applications of Computational Biology and Bioinformatics, 15th International Conference, PACBB 2021
Editors	Miguel Rocha, Florentino Fdez-Riverola, Mohd Saberi Mohamad, Roberto Casado-Vara
Publisher	Springer Science and Business Media Deutschland GmbH
Pages	126-135
Number of pages	10
ISBN (Print)	9783030862572
DOIs	https://doi.org/10.1007/978-3-030-86258-9_13
Publication status	Published - 2022
Event	15th International Conference on Practical Applications of Computational Biology and Bioinformatics, PACBB 2021 - Salamanca, Spain Duration: 6 Oct 2021 → 8 Oct 2021

Publication series

Name	Lecture Notes in Networks and Systems
Volume	325 LNNS
ISSN (Print)	2367-3370
ISSN (Electronic)	2367-3389

Conference

Conference	15th International Conference on Practical Applications of Computational Biology and Bioinformatics, PACBB 2021
Country/Territory	Spain
City	Salamanca
Period	6/10/21 → 8/10/21

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Acute Myeloid Leukaemia
DNA methylation
Epigenetics
Prognostic markers
Sex disparity
Survival analysis

ASJC Scopus subject areas

Control and Systems Engineering
Signal Processing
Computer Networks and Communications

Access to Document

10.1007/978-3-030-86258-9_13

Cite this

Cecotka, A., Krol, L., O’Brien, G., Badie, C., & Polanska, J. (2022). May Gender Have an Impact on Methylation Profile and Survival Prognosis in Acute Myeloid Leukemia? In M. Rocha, F. Fdez-Riverola, M. S. Mohamad, & R. Casado-Vara (Eds.), Practical Applications of Computational Biology and Bioinformatics, 15th International Conference, PACBB 2021 (pp. 126-135). (Lecture Notes in Networks and Systems; Vol. 325 LNNS). Springer Science and Business Media Deutschland GmbH. https://doi.org/10.1007/978-3-030-86258-9_13

Cecotka, Agnieszka ; Krol, Lukasz ; O’Brien, Grainne et al. / May Gender Have an Impact on Methylation Profile and Survival Prognosis in Acute Myeloid Leukemia?. Practical Applications of Computational Biology and Bioinformatics, 15th International Conference, PACBB 2021. editor / Miguel Rocha ; Florentino Fdez-Riverola ; Mohd Saberi Mohamad ; Roberto Casado-Vara. Springer Science and Business Media Deutschland GmbH, 2022. pp. 126-135 (Lecture Notes in Networks and Systems).

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title = "May Gender Have an Impact on Methylation Profile and Survival Prognosis in Acute Myeloid Leukemia?",

abstract = "DNA methylation alteration is crucial for the initiation and development of Acute Myeloid Leukemia. However, only a few epigenetic biomarkers of AML have been discovered so far. DNA methylation of CpG rich gene promoters has the highest impact on gene expression level, so biomarkers should be sought in these genomic regions. Principal Component Analysis of methylation level reveals that male and female AML patients differ in CpG rich-gene promoters. Statistical comparison between males and females conducted for each CpG site confirms statistical relevance of differences only in CpG-rich promoter regions. P-value integration results in detection of AML-specific hypermethylated genomic regions and shows that almost 10\% of CpG-rich promoters are differentially methylated between males and females. Functional analysis of genes with differentially methylated promoters in AML results in 322 enrichments for women and 1893 for men. Genes are mainly related to homeobox, cell development and morphogenesis. Survival analysis indentifies gender-specific potential epigenomic prognostic markers. Dissimilarity of the survival-significant gene sets between males and females is 75\%.",

keywords = "Acute Myeloid Leukaemia, DNA methylation, Epigenetics, Prognostic markers, Sex disparity, Survival analysis",

author = "Agnieszka Cecotka and Lukasz Krol and Grainne O{\textquoteright}Brien and Christophe Badie and Joanna Polanska",

note = "Publisher Copyright: {\textcopyright} 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG.; 15th International Conference on Practical Applications of Computational Biology and Bioinformatics, PACBB 2021 ; Conference date: 06-10-2021 Through 08-10-2021",

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Cecotka, A, Krol, L, O’Brien, G, Badie, C & Polanska, J 2022, May Gender Have an Impact on Methylation Profile and Survival Prognosis in Acute Myeloid Leukemia? in M Rocha, F Fdez-Riverola, MS Mohamad & R Casado-Vara (eds), Practical Applications of Computational Biology and Bioinformatics, 15th International Conference, PACBB 2021. Lecture Notes in Networks and Systems, vol. 325 LNNS, Springer Science and Business Media Deutschland GmbH, pp. 126-135, 15th International Conference on Practical Applications of Computational Biology and Bioinformatics, PACBB 2021, Salamanca, Spain, 6/10/21. https://doi.org/10.1007/978-3-030-86258-9_13

May Gender Have an Impact on Methylation Profile and Survival Prognosis in Acute Myeloid Leukemia? / Cecotka, Agnieszka; Krol, Lukasz; O’Brien, Grainne et al.
Practical Applications of Computational Biology and Bioinformatics, 15th International Conference, PACBB 2021. ed. / Miguel Rocha; Florentino Fdez-Riverola; Mohd Saberi Mohamad; Roberto Casado-Vara. Springer Science and Business Media Deutschland GmbH, 2022. p. 126-135 (Lecture Notes in Networks and Systems; Vol. 325 LNNS).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review