Investigation of ketoconazole diffusion into collodion membranes using step-scan FTIR-PAS technique

J. Bodzenta; B. D. Hanh; A. Kaźmierczak; R. H.H. Neubert; S. Wartewig

doi:10.1051/jp4:2004117003

Investigation of ketoconazole diffusion into collodion membranes using step-scan FTIR-PAS technique

J. Bodzenta
, B. D. Hanh
, A. Kaźmierczak
, R. H.H. Neubert
, S. Wartewig

Division of Applied Physics (RIF/RIF3)

Martin Luther University Halle-Wittenberg
Silesian University of Technology
Institute of Applied Dermatopharmacy

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Results obtained from step-scan Fourier transform infrared photoacoustic spectroscopic (FTIR-PAS) experiments on ketoconazole diffusion into artificial dodecanol-collodion (DDC) membrane are presented. Measurements were performed for two frequencies of 13 Hz and 54 Hz at the spectral range (500÷4500) cm^-1. Both in-phase and quadrature components of photoacoustic signal were registered. Analysis of ketoconazole diffusion was carried out for 1512 cm^-1 line, whose intensity showed strong dependence on drug concentration. This analysis based on earlier proposed theoretical model of diffusion in a layered system. Experimental dependencies were fitted with theoretical curves using multiparameter fitting procedure. It allowed determination of the diffusion coefficient of ketoconazole in DDC membrane D = (2.1±0.5)·10^-9 cm²s^-1. Obtained results confirmed usability of step-scan FTIR-PAS techniques in investigations of diffusion processes.

Original language	English
Pages (from-to)	13-16
Number of pages	4
Journal	Journal De Physique. IV : JP
Volume	117
DOIs	https://doi.org/10.1051/jp4:2004117003
Publication status	Published - 2004

ASJC Scopus subject areas

General Physics and Astronomy

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10.1051/jp4:2004117003

Cite this

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title = "Investigation of ketoconazole diffusion into collodion membranes using step-scan FTIR-PAS technique",

abstract = "Results obtained from step-scan Fourier transform infrared photoacoustic spectroscopic (FTIR-PAS) experiments on ketoconazole diffusion into artificial dodecanol-collodion (DDC) membrane are presented. Measurements were performed for two frequencies of 13 Hz and 54 Hz at the spectral range (500{\textdiv}4500) cm-1. Both in-phase and quadrature components of photoacoustic signal were registered. Analysis of ketoconazole diffusion was carried out for 1512 cm-1 line, whose intensity showed strong dependence on drug concentration. This analysis based on earlier proposed theoretical model of diffusion in a layered system. Experimental dependencies were fitted with theoretical curves using multiparameter fitting procedure. It allowed determination of the diffusion coefficient of ketoconazole in DDC membrane D = (2.1±0.5)·10-9 cm2s-1. Obtained results confirmed usability of step-scan FTIR-PAS techniques in investigations of diffusion processes.",

author = "J. Bodzenta and Hanh, \{B. D.\} and A. Ka{\'z}mierczak and Neubert, \{R. H.H.\} and S. Wartewig",

year = "2004",

doi = "10.1051/jp4:2004117003",

language = "English",

volume = "117",

pages = "13--16",

journal = "Journal De Physique. IV : JP",

issn = "1155-4339",

publisher = "EDP Sciences",

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TY - JOUR

T1 - Investigation of ketoconazole diffusion into collodion membranes using step-scan FTIR-PAS technique

AU - Bodzenta, J.

AU - Hanh, B. D.

AU - Kaźmierczak, A.

AU - Neubert, R. H.H.

AU - Wartewig, S.

PY - 2004

Y1 - 2004

N2 - Results obtained from step-scan Fourier transform infrared photoacoustic spectroscopic (FTIR-PAS) experiments on ketoconazole diffusion into artificial dodecanol-collodion (DDC) membrane are presented. Measurements were performed for two frequencies of 13 Hz and 54 Hz at the spectral range (500÷4500) cm-1. Both in-phase and quadrature components of photoacoustic signal were registered. Analysis of ketoconazole diffusion was carried out for 1512 cm-1 line, whose intensity showed strong dependence on drug concentration. This analysis based on earlier proposed theoretical model of diffusion in a layered system. Experimental dependencies were fitted with theoretical curves using multiparameter fitting procedure. It allowed determination of the diffusion coefficient of ketoconazole in DDC membrane D = (2.1±0.5)·10-9 cm2s-1. Obtained results confirmed usability of step-scan FTIR-PAS techniques in investigations of diffusion processes.

AB - Results obtained from step-scan Fourier transform infrared photoacoustic spectroscopic (FTIR-PAS) experiments on ketoconazole diffusion into artificial dodecanol-collodion (DDC) membrane are presented. Measurements were performed for two frequencies of 13 Hz and 54 Hz at the spectral range (500÷4500) cm-1. Both in-phase and quadrature components of photoacoustic signal were registered. Analysis of ketoconazole diffusion was carried out for 1512 cm-1 line, whose intensity showed strong dependence on drug concentration. This analysis based on earlier proposed theoretical model of diffusion in a layered system. Experimental dependencies were fitted with theoretical curves using multiparameter fitting procedure. It allowed determination of the diffusion coefficient of ketoconazole in DDC membrane D = (2.1±0.5)·10-9 cm2s-1. Obtained results confirmed usability of step-scan FTIR-PAS techniques in investigations of diffusion processes.

UR - https://www.scopus.com/pages/publications/7044239524

U2 - 10.1051/jp4:2004117003

DO - 10.1051/jp4:2004117003

M3 - Article

AN - SCOPUS:7044239524

SN - 1155-4339

VL - 117

SP - 13

EP - 16

JO - Journal De Physique. IV : JP

JF - Journal De Physique. IV : JP

ER -

Investigation of ketoconazole diffusion into collodion membranes using step-scan FTIR-PAS technique

Abstract

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