Introduction to the model

Irena Roterman; Katarzyna Stapor; Piotr Fabian; Dawid Dułak; Leszek Konieczny

doi:10.1016/B978-0-443-40475-7.00005-5

Introduction to the model

Irena Roterman
, Katarzyna Stapor
, Piotr Fabian
, Dawid Dułak
, Leszek Konieczny

Jagiellonian University Medical College
Jagiellonian University in Kraków

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

The amyloid transformation requires partial unfolding. Model for controlled unfolding is presented based on early stage (ES) intermediate construction for folding model in silico. The applicability of hydrophobic collapse as the effect of environment influence on folding process is described.

Original language	English
Title of host publication	Simulating Protein Folding in Variable Environmental Conditions
Subtitle of host publication	Transformation from Globular Proteins to Amyloids
Publisher	Elsevier
Pages	13-45
Number of pages	33
ISBN (Electronic)	9780443404757
ISBN (Print)	9780443404764
DOIs	https://doi.org/10.1016/B978-0-443-40475-7.00005-5
Publication status	Published - 1 Jan 2026

Keywords

Amyloid
Early stage intermediate
Environment influence on folding
Folding process
Hydrophobic collapse
Partial unfolding
Planarity of amyloid
Tertiary structure

ASJC Scopus subject areas

General Biochemistry,Genetics and Molecular Biology

Access to Document

10.1016/B978-0-443-40475-7.00005-5

Cite this

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AU - Roterman, Irena

AU - Stapor, Katarzyna

AU - Fabian, Piotr

AU - Dułak, Dawid

AU - Konieczny, Leszek

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Y1 - 2026/1/1

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AB - The amyloid transformation requires partial unfolding. Model for controlled unfolding is presented based on early stage (ES) intermediate construction for folding model in silico. The applicability of hydrophobic collapse as the effect of environment influence on folding process is described.

KW - Amyloid

KW - Early stage intermediate

KW - Environment influence on folding

KW - Folding process

KW - Hydrophobic collapse

KW - Partial unfolding

KW - Planarity of amyloid

KW - Tertiary structure

UR - https://www.scopus.com/pages/publications/105033755057

U2 - 10.1016/B978-0-443-40475-7.00005-5

DO - 10.1016/B978-0-443-40475-7.00005-5

M3 - Chapter

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SN - 9780443404764

SP - 13

EP - 45

BT - Simulating Protein Folding in Variable Environmental Conditions

PB - Elsevier

ER -

Introduction to the model

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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