In silico analysis of interactions between NFkB and HSF pathways

Jaroslaw Smieja; Malgorzata Kardynska; Anna Naumowicz; Patryk Janus; Piotr Widlak; Marek Kimmel

doi:10.5220/0005256602010206

In silico analysis of interactions between NFkB and HSF pathways

Jaroslaw Smieja
, Malgorzata Kardynska
, Anna Naumowicz
, Patryk Janus
, Piotr Widlak
, Marek Kimmel

Department of Systems Biology and Engineering (RAU/RAU1)

Silesian University of Technology
Maria Sklodowska-Curie Institute of Oncology
Rice University

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

2 Citations (Scopus)

Abstract

Motivation: Inhibition of NFkB pathway is known to promote apoptosis and therefore may constitute one of the goals in anticancer therapies. Experimental results show that heat shock induces such inhibition in cancer cells. However, the mechanisms of interactions between heat shock and NFkB pathways are not fully understood yet. Development of a combined mathematical model of these pathways and its subsequent computational analysis should help to uncover these mechanisms and determine the time window in which heat shock treatment preceding chemotherapy would be the most efficient. Results: An original mathematical model has been developed, allowing for computational testing of various hypotheses concerning main sources of interplay between HSF and NFkB pathways. Computational analysis strongly suggests that the competition for IKK, known from literature, cannot be the only mechanism. Two plausible hypotheses are that either a kinase activating IKK can misfold due to heat shock or that heat shock affects TNF receptors, blocking activation of NFkB pathway at the cell membrane.

Original language	English
Title of host publication	BIOINFORMATICS 2015 - 6th International Conference on Bioinformatics Models, Methods and Algorithms, Proceedings; Part of 8th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2015
Editors	Oscar Pastor, Christine Sinoquet, Ana Fred, Hugo Gamboa, Dirk Elias
Publisher	SciTePress
Pages	201-206
Number of pages	6
ISBN (Electronic)	9789897580703
DOIs	https://doi.org/10.5220/0005256602010206
Publication status	Published - 2015
Event	6th International Conference on Bioinformatics Models, Methods and Algorithms, BIOINFORMATICS 2015 - Lisbon, Portugal Duration: 12 Jan 2015 → 15 Jan 2015

Publication series

Name	BIOINFORMATICS 2015 - 6th International Conference on Bioinformatics Models, Methods and Algorithms, Proceedings; Part of 8th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2015

Conference

Conference	6th International Conference on Bioinformatics Models, Methods and Algorithms, BIOINFORMATICS 2015
Country/Territory	Portugal
City	Lisbon
Period	12/01/15 → 15/01/15

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

HSF
HSP
Heat shock
NFkB
Signalling pathways

ASJC Scopus subject areas

Biomedical Engineering
Health Informatics
Architecture

Access to Document

10.5220/0005256602010206

Cite this

Smieja, J., Kardynska, M., Naumowicz, A., Janus, P., Widlak, P., & Kimmel, M. (2015). In silico analysis of interactions between NFkB and HSF pathways. In O. Pastor, C. Sinoquet, A. Fred, H. Gamboa, & D. Elias (Eds.), BIOINFORMATICS 2015 - 6th International Conference on Bioinformatics Models, Methods and Algorithms, Proceedings; Part of 8th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2015 (pp. 201-206). (BIOINFORMATICS 2015 - 6th International Conference on Bioinformatics Models, Methods and Algorithms, Proceedings; Part of 8th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2015). SciTePress. https://doi.org/10.5220/0005256602010206

Smieja, Jaroslaw ; Kardynska, Malgorzata ; Naumowicz, Anna et al. / In silico analysis of interactions between NFkB and HSF pathways. BIOINFORMATICS 2015 - 6th International Conference on Bioinformatics Models, Methods and Algorithms, Proceedings; Part of 8th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2015. editor / Oscar Pastor ; Christine Sinoquet ; Ana Fred ; Hugo Gamboa ; Dirk Elias. SciTePress, 2015. pp. 201-206 (BIOINFORMATICS 2015 - 6th International Conference on Bioinformatics Models, Methods and Algorithms, Proceedings; Part of 8th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2015).

@inproceedings{a4158e3aa1a24cbe8bb8575024768daf,

title = "In silico analysis of interactions between NFkB and HSF pathways",

abstract = "Motivation: Inhibition of NFkB pathway is known to promote apoptosis and therefore may constitute one of the goals in anticancer therapies. Experimental results show that heat shock induces such inhibition in cancer cells. However, the mechanisms of interactions between heat shock and NFkB pathways are not fully understood yet. Development of a combined mathematical model of these pathways and its subsequent computational analysis should help to uncover these mechanisms and determine the time window in which heat shock treatment preceding chemotherapy would be the most efficient. Results: An original mathematical model has been developed, allowing for computational testing of various hypotheses concerning main sources of interplay between HSF and NFkB pathways. Computational analysis strongly suggests that the competition for IKK, known from literature, cannot be the only mechanism. Two plausible hypotheses are that either a kinase activating IKK can misfold due to heat shock or that heat shock affects TNF receptors, blocking activation of NFkB pathway at the cell membrane.",

keywords = "HSF, HSP, Heat shock, NFkB, Signalling pathways",

author = "Jaroslaw Smieja and Malgorzata Kardynska and Anna Naumowicz and Patryk Janus and Piotr Widlak and Marek Kimmel",

year = "2015",

doi = "10.5220/0005256602010206",

language = "English",

series = "BIOINFORMATICS 2015 - 6th International Conference on Bioinformatics Models, Methods and Algorithms, Proceedings; Part of 8th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2015",

publisher = "SciTePress",

pages = "201--206",

editor = "Oscar Pastor and Christine Sinoquet and Ana Fred and Hugo Gamboa and Dirk Elias",

booktitle = "BIOINFORMATICS 2015 - 6th International Conference on Bioinformatics Models, Methods and Algorithms, Proceedings; Part of 8th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2015",

note = "6th International Conference on Bioinformatics Models, Methods and Algorithms, BIOINFORMATICS 2015 ; Conference date: 12-01-2015 Through 15-01-2015",

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Smieja, J , Kardynska, M, Naumowicz, A, Janus, P, Widlak, P & Kimmel, M 2015, In silico analysis of interactions between NFkB and HSF pathways. in O Pastor, C Sinoquet, A Fred, H Gamboa & D Elias (eds), BIOINFORMATICS 2015 - 6th International Conference on Bioinformatics Models, Methods and Algorithms, Proceedings; Part of 8th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2015. BIOINFORMATICS 2015 - 6th International Conference on Bioinformatics Models, Methods and Algorithms, Proceedings; Part of 8th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2015, SciTePress, pp. 201-206, 6th International Conference on Bioinformatics Models, Methods and Algorithms, BIOINFORMATICS 2015, Lisbon, Portugal, 12/01/15. https://doi.org/10.5220/0005256602010206

In silico analysis of interactions between NFkB and HSF pathways. / Smieja, Jaroslaw ; Kardynska, Malgorzata; Naumowicz, Anna et al.
BIOINFORMATICS 2015 - 6th International Conference on Bioinformatics Models, Methods and Algorithms, Proceedings; Part of 8th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2015. ed. / Oscar Pastor; Christine Sinoquet; Ana Fred; Hugo Gamboa; Dirk Elias. SciTePress, 2015. p. 201-206 (BIOINFORMATICS 2015 - 6th International Conference on Bioinformatics Models, Methods and Algorithms, Proceedings; Part of 8th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2015).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - In silico analysis of interactions between NFkB and HSF pathways

AU - Smieja, Jaroslaw

AU - Kardynska, Malgorzata

AU - Naumowicz, Anna

AU - Janus, Patryk

AU - Widlak, Piotr

AU - Kimmel, Marek

PY - 2015

Y1 - 2015

N2 - Motivation: Inhibition of NFkB pathway is known to promote apoptosis and therefore may constitute one of the goals in anticancer therapies. Experimental results show that heat shock induces such inhibition in cancer cells. However, the mechanisms of interactions between heat shock and NFkB pathways are not fully understood yet. Development of a combined mathematical model of these pathways and its subsequent computational analysis should help to uncover these mechanisms and determine the time window in which heat shock treatment preceding chemotherapy would be the most efficient. Results: An original mathematical model has been developed, allowing for computational testing of various hypotheses concerning main sources of interplay between HSF and NFkB pathways. Computational analysis strongly suggests that the competition for IKK, known from literature, cannot be the only mechanism. Two plausible hypotheses are that either a kinase activating IKK can misfold due to heat shock or that heat shock affects TNF receptors, blocking activation of NFkB pathway at the cell membrane.

AB - Motivation: Inhibition of NFkB pathway is known to promote apoptosis and therefore may constitute one of the goals in anticancer therapies. Experimental results show that heat shock induces such inhibition in cancer cells. However, the mechanisms of interactions between heat shock and NFkB pathways are not fully understood yet. Development of a combined mathematical model of these pathways and its subsequent computational analysis should help to uncover these mechanisms and determine the time window in which heat shock treatment preceding chemotherapy would be the most efficient. Results: An original mathematical model has been developed, allowing for computational testing of various hypotheses concerning main sources of interplay between HSF and NFkB pathways. Computational analysis strongly suggests that the competition for IKK, known from literature, cannot be the only mechanism. Two plausible hypotheses are that either a kinase activating IKK can misfold due to heat shock or that heat shock affects TNF receptors, blocking activation of NFkB pathway at the cell membrane.

KW - HSF

KW - HSP

KW - Heat shock

KW - NFkB

KW - Signalling pathways

UR - https://www.scopus.com/pages/publications/84938883086

U2 - 10.5220/0005256602010206

DO - 10.5220/0005256602010206

M3 - Conference contribution

AN - SCOPUS:84938883086

T3 - BIOINFORMATICS 2015 - 6th International Conference on Bioinformatics Models, Methods and Algorithms, Proceedings; Part of 8th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2015

SP - 201

EP - 206

BT - BIOINFORMATICS 2015 - 6th International Conference on Bioinformatics Models, Methods and Algorithms, Proceedings; Part of 8th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2015

A2 - Pastor, Oscar

A2 - Sinoquet, Christine

A2 - Fred, Ana

A2 - Gamboa, Hugo

A2 - Elias, Dirk

PB - SciTePress

T2 - 6th International Conference on Bioinformatics Models, Methods and Algorithms, BIOINFORMATICS 2015

Y2 - 12 January 2015 through 15 January 2015

ER -

Smieja J , Kardynska M, Naumowicz A, Janus P, Widlak P, Kimmel M. In silico analysis of interactions between NFkB and HSF pathways. In Pastor O, Sinoquet C, Fred A, Gamboa H, Elias D, editors, BIOINFORMATICS 2015 - 6th International Conference on Bioinformatics Models, Methods and Algorithms, Proceedings; Part of 8th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2015. SciTePress. 2015. p. 201-206. (BIOINFORMATICS 2015 - 6th International Conference on Bioinformatics Models, Methods and Algorithms, Proceedings; Part of 8th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2015). doi: 10.5220/0005256602010206

In silico analysis of interactions between NFkB and HSF pathways

Abstract

Publication series

Conference

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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Cite this