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Identification of the compound subjective rule interestingness measure for rule-based functional description of genes

  • Institute of Innovative Technologies EMAG

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Methods for automatic functional description of gene groups are useful tools supporting the interpretation of biological experiments. The RuleGO algorithm provides functional interpretation of gene groups in a form of logical rules including combinations of Gene Ontology terms in their premises. The number of rules generated by the algorithm is usually huge and additional methods of rule quality evaluation and filtration are required in order to select the most interesting ones. In the paper, we apply the multicriteria decision making UTA method to obtain a ranking of rules based on subjective expert opinion which is provided in a form of an ordered list of several rules. The presented approach is applied to the well known data set from microarray experiment and the results are compared with the standard RuleGO compound rule quality measure.

Original languageEnglish
Title of host publicationArtificial Intelligence
Subtitle of host publicationMethodology, Systems, and Applications - 15th International Conference, AIMSA 2012, Proceedings
Pages125-134
Number of pages10
DOIs
Publication statusPublished - 2012
Event15th International Conference on Artificial Intelligence: Methodology, Systems, and Applications, AIMSA 2012 - Varna, Bulgaria
Duration: 12 Sept 201215 Sept 2012

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume7557 LNAI
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Conference

Conference15th International Conference on Artificial Intelligence: Methodology, Systems, and Applications, AIMSA 2012
Country/TerritoryBulgaria
CityVarna
Period12/09/1215/09/12

Keywords

  • Gene Ontology
  • bioinformatics
  • functional annotations
  • multicriteria decision making
  • rule interestingness
  • rule quality

ASJC Scopus subject areas

  • Theoretical Computer Science
  • General Computer Science

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