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Evaluation of semantic term and gene similarity measures

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

In this paper we present the results of the research verifying how the functional description of genes contained in Gene Ontology database is related to genes expression values recorded during biological experiments. We compare several different gene similarity measures and semantic term similarity measures, and evaluate how the similarity of genes based on Gene Ontology terms is correlated with similarity of genes based on expression profiles. The analysis are preformed on three different datasets and we show that there is no single term similarity measure that always gives the best correlation results. The choice of the best term similarity measure depends on dataset characteristic.

Original languageEnglish
Title of host publicationPattern Recognition and Machine Intelligence - 4th International Conference, PReMI 2011, Proceedings
Pages406-411
Number of pages6
DOIs
Publication statusPublished - 2011
Event4th International Conference on Pattern Recognition and Machine Intelligence, PReMI-2011 - Moscow, Russian Federation
Duration: 27 Jun 20111 Jul 2011

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume6744 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Conference

Conference4th International Conference on Pattern Recognition and Machine Intelligence, PReMI-2011
Country/TerritoryRussian Federation
CityMoscow
Period27/06/111/07/11

Keywords

  • Gene Ontology database
  • experssion analysis
  • genes similarity
  • semantic term similarity

ASJC Scopus subject areas

  • Theoretical Computer Science
  • General Computer Science

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