EHPG iron(III) complexes as potential contrast agents for MRI

Nikodem Kuźnik; Paweł Jewuła; Lidia Oczek; Sylwia Kozłowicz; Artur Grucela; Wojciech Domagała

EHPG iron(III) complexes as potential contrast agents for MRI

Nikodem Kuźnik
, Paweł Jewuła
, Lidia Oczek
, Sylwia Kozłowicz
, Artur Grucela
, Wojciech Domagała

Silesian University of Technology

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

A series of EHPG ligands and complexes were obtained. The derivatives of choice were p-OMe, 3,4-dimethyl, p-NHA-c and p-Ph substituted ones. The complexes were characterized by NMR relaxation decay (T₁), EPR and cyclic voltammetry (CV). r₁ Relaxivity of the Fe-EHPG-OMe, Fe-EHPG-Ph derivatives was found higher than that of Fe-EHPG. EPR measurements at liquid nitrogen temperature indicate a typical rhombohedral structure for both rac- and meso-diastereoisomers of the EHPG complexes. CV revealed the redox inactivity of the Fe-EHPG complexes at physiological conditions. Interpretation and discussion of the results is presented.

Original language	English
Pages (from-to)	87-93
Number of pages	7
Journal	Acta Chimica Slovenica
Volume	61
Issue number	1
Publication status	Published - 2014

Keywords

Contrast agents
EHPG-N,N'-ethylenebis[(2-hydroxyphenyl)glycine]
Fe(III) complexes
Phenolates
Relaxivity

ASJC Scopus subject areas

General Medicine

Cite this

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title = "EHPG iron(III) complexes as potential contrast agents for MRI",

abstract = "A series of EHPG ligands and complexes were obtained. The derivatives of choice were p-OMe, 3,4-dimethyl, p-NHA-c and p-Ph substituted ones. The complexes were characterized by NMR relaxation decay (T1), EPR and cyclic voltammetry (CV). r1 Relaxivity of the Fe-EHPG-OMe, Fe-EHPG-Ph derivatives was found higher than that of Fe-EHPG. EPR measurements at liquid nitrogen temperature indicate a typical rhombohedral structure for both rac- and meso-diastereoisomers of the EHPG complexes. CV revealed the redox inactivity of the Fe-EHPG complexes at physiological conditions. Interpretation and discussion of the results is presented.",

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author = "Nikodem Ku{\'z}nik and Pawe{\l} Jewu{\l}a and Lidia Oczek and Sylwia Koz{\l}owicz and Artur Grucela and Wojciech Domaga{\l}a",

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language = "English",

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TY - JOUR

T1 - EHPG iron(III) complexes as potential contrast agents for MRI

AU - Kuźnik, Nikodem

AU - Jewuła, Paweł

AU - Oczek, Lidia

AU - Kozłowicz, Sylwia

AU - Grucela, Artur

AU - Domagała, Wojciech

PY - 2014

Y1 - 2014

N2 - A series of EHPG ligands and complexes were obtained. The derivatives of choice were p-OMe, 3,4-dimethyl, p-NHA-c and p-Ph substituted ones. The complexes were characterized by NMR relaxation decay (T1), EPR and cyclic voltammetry (CV). r1 Relaxivity of the Fe-EHPG-OMe, Fe-EHPG-Ph derivatives was found higher than that of Fe-EHPG. EPR measurements at liquid nitrogen temperature indicate a typical rhombohedral structure for both rac- and meso-diastereoisomers of the EHPG complexes. CV revealed the redox inactivity of the Fe-EHPG complexes at physiological conditions. Interpretation and discussion of the results is presented.

AB - A series of EHPG ligands and complexes were obtained. The derivatives of choice were p-OMe, 3,4-dimethyl, p-NHA-c and p-Ph substituted ones. The complexes were characterized by NMR relaxation decay (T1), EPR and cyclic voltammetry (CV). r1 Relaxivity of the Fe-EHPG-OMe, Fe-EHPG-Ph derivatives was found higher than that of Fe-EHPG. EPR measurements at liquid nitrogen temperature indicate a typical rhombohedral structure for both rac- and meso-diastereoisomers of the EHPG complexes. CV revealed the redox inactivity of the Fe-EHPG complexes at physiological conditions. Interpretation and discussion of the results is presented.

KW - Contrast agents

KW - EHPG-N,N'-ethylenebis[(2-hydroxyphenyl)glycine]

KW - Fe(III) complexes

KW - Phenolates

KW - Relaxivity

UR - https://www.scopus.com/pages/publications/84897533763

M3 - Article

C2 - 24664331

AN - SCOPUS:84897533763

SN - 1318-0207

VL - 61

SP - 87

EP - 93

JO - Acta Chimica Slovenica

JF - Acta Chimica Slovenica

IS - 1

ER -

EHPG iron(III) complexes as potential contrast agents for MRI

Abstract

Keywords

ASJC Scopus subject areas

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