Abstract
Controllability of combination of antiangiogenic treatment and chemotherapy is considered. A model used in the paper is a finite-dimensional dynamical control system described by second order semilinear time invariant ordinary differential state equations. Using a generalized open mapping theorem, sufficient conditions for constrained local controllability in a given time interval are formulated and proved. These conditions require verification of constrained global controllability of the associated linear second-order dynamical control system.
| Original language | English |
|---|---|
| Pages (from-to) | 123-138 |
| Number of pages | 16 |
| Journal | Control and Cybernetics |
| Volume | 42 |
| Issue number | 1 |
| Publication status | Published - 2013 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Biomathematical modelling
- Cancer therapy
- Controllability
- Semilinear systems
ASJC Scopus subject areas
- Control and Systems Engineering
- Modeling and Simulation
- Applied Mathematics
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