A Minimal Model of Cancer Growth, Metastasis and Treatment

Jaroslaw Smieja; Andrzej Swierniak; Marek Kimmel

doi:10.1007/978-981-19-8234-7_44

A Minimal Model of Cancer Growth, Metastasis and Treatment

Department of Systems Biology and Engineering (RAU/RAU1)

Rice University

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

3 Citations (Scopus)

Abstract

The paper is concerned with modeling cancer growth, metastasis and response to anticancer treatment in a heterogeneous population of patients. Following a discussion of existing models, multicompartmental models are compared using Kaplan-Meier survival curves. Subsequently, different death conditions are analyzed, leading to the final conclusion that a simple, two-compartmental model describes primary and metastatic tumors well enough but death condition must fine-tuned to available clinical survival curves.

Original language	English
Title of host publication	Recent Challenges in Intelligent Information and Database Systems - 14th Asian Conference, ACIIDS 2022, Proceedings
Editors	Edward Szczerbicki, Krystian Wojtkiewicz, Sinh Van Nguyen, Marcin Pietranik, Marek Krótkiewicz
Publisher	Springer Science and Business Media Deutschland GmbH
Pages	566-577
Number of pages	12
ISBN (Print)	9789811982330
DOIs	https://doi.org/10.1007/978-981-19-8234-7_44
Publication status	Published - 2022
Event	14th Asian Conference on Intelligent Information and Database Systems, ACIIDS 2022 - Ho Chi Minh City, Viet Nam Duration: 28 Nov 2022 → 30 Nov 2022

Publication series

Name	Communications in Computer and Information Science
Volume	1716 CCIS
ISSN (Print)	1865-0929
ISSN (Electronic)	1865-0937

Conference

Conference	14th Asian Conference on Intelligent Information and Database Systems, ACIIDS 2022
Country/Territory	Viet Nam
City	Ho Chi Minh City
Period	28/11/22 → 30/11/22

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Kaplan-Meyer survival curves
Metastasis
Modeling of cancer growth

ASJC Scopus subject areas

General Computer Science
General Mathematics

Access to Document

10.1007/978-981-19-8234-7_44

Cite this

Smieja, J., Swierniak, A., & Kimmel, M. (2022). A Minimal Model of Cancer Growth, Metastasis and Treatment. In E. Szczerbicki, K. Wojtkiewicz, S. V. Nguyen, M. Pietranik, & M. Krótkiewicz (Eds.), Recent Challenges in Intelligent Information and Database Systems - 14th Asian Conference, ACIIDS 2022, Proceedings (pp. 566-577). (Communications in Computer and Information Science; Vol. 1716 CCIS). Springer Science and Business Media Deutschland GmbH. https://doi.org/10.1007/978-981-19-8234-7_44

Smieja, Jaroslaw ; Swierniak, Andrzej ; Kimmel, Marek. / A Minimal Model of Cancer Growth, Metastasis and Treatment. Recent Challenges in Intelligent Information and Database Systems - 14th Asian Conference, ACIIDS 2022, Proceedings. editor / Edward Szczerbicki ; Krystian Wojtkiewicz ; Sinh Van Nguyen ; Marcin Pietranik ; Marek Krótkiewicz. Springer Science and Business Media Deutschland GmbH, 2022. pp. 566-577 (Communications in Computer and Information Science).

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abstract = "The paper is concerned with modeling cancer growth, metastasis and response to anticancer treatment in a heterogeneous population of patients. Following a discussion of existing models, multicompartmental models are compared using Kaplan-Meier survival curves. Subsequently, different death conditions are analyzed, leading to the final conclusion that a simple, two-compartmental model describes primary and metastatic tumors well enough but death condition must fine-tuned to available clinical survival curves.",

keywords = "Kaplan-Meyer survival curves, Metastasis, Modeling of cancer growth",

author = "Jaroslaw Smieja and Andrzej Swierniak and Marek Kimmel",

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Smieja, J , Swierniak, A & Kimmel, M 2022, A Minimal Model of Cancer Growth, Metastasis and Treatment. in E Szczerbicki, K Wojtkiewicz, SV Nguyen, M Pietranik & M Krótkiewicz (eds), Recent Challenges in Intelligent Information and Database Systems - 14th Asian Conference, ACIIDS 2022, Proceedings. Communications in Computer and Information Science, vol. 1716 CCIS, Springer Science and Business Media Deutschland GmbH, pp. 566-577, 14th Asian Conference on Intelligent Information and Database Systems, ACIIDS 2022, Ho Chi Minh City, Viet Nam, 28/11/22. https://doi.org/10.1007/978-981-19-8234-7_44

A Minimal Model of Cancer Growth, Metastasis and Treatment. / Smieja, Jaroslaw ; Swierniak, Andrzej ; Kimmel, Marek.
Recent Challenges in Intelligent Information and Database Systems - 14th Asian Conference, ACIIDS 2022, Proceedings. ed. / Edward Szczerbicki; Krystian Wojtkiewicz; Sinh Van Nguyen; Marcin Pietranik; Marek Krótkiewicz. Springer Science and Business Media Deutschland GmbH, 2022. p. 566-577 (Communications in Computer and Information Science; Vol. 1716 CCIS).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - A Minimal Model of Cancer Growth, Metastasis and Treatment

AU - Smieja, Jaroslaw

AU - Swierniak, Andrzej

AU - Kimmel, Marek

PY - 2022

Y1 - 2022

N2 - The paper is concerned with modeling cancer growth, metastasis and response to anticancer treatment in a heterogeneous population of patients. Following a discussion of existing models, multicompartmental models are compared using Kaplan-Meier survival curves. Subsequently, different death conditions are analyzed, leading to the final conclusion that a simple, two-compartmental model describes primary and metastatic tumors well enough but death condition must fine-tuned to available clinical survival curves.

AB - The paper is concerned with modeling cancer growth, metastasis and response to anticancer treatment in a heterogeneous population of patients. Following a discussion of existing models, multicompartmental models are compared using Kaplan-Meier survival curves. Subsequently, different death conditions are analyzed, leading to the final conclusion that a simple, two-compartmental model describes primary and metastatic tumors well enough but death condition must fine-tuned to available clinical survival curves.

KW - Kaplan-Meyer survival curves

KW - Metastasis

KW - Modeling of cancer growth

UR - https://www.scopus.com/pages/publications/85144235537

U2 - 10.1007/978-981-19-8234-7_44

DO - 10.1007/978-981-19-8234-7_44

M3 - Conference contribution

AN - SCOPUS:85144235537

SN - 9789811982330

T3 - Communications in Computer and Information Science

SP - 566

EP - 577

BT - Recent Challenges in Intelligent Information and Database Systems - 14th Asian Conference, ACIIDS 2022, Proceedings

A2 - Szczerbicki, Edward

A2 - Wojtkiewicz, Krystian

A2 - Nguyen, Sinh Van

A2 - Pietranik, Marcin

A2 - Krótkiewicz, Marek

PB - Springer Science and Business Media Deutschland GmbH

T2 - 14th Asian Conference on Intelligent Information and Database Systems, ACIIDS 2022

Y2 - 28 November 2022 through 30 November 2022

ER -

Smieja J , Swierniak A , Kimmel M. A Minimal Model of Cancer Growth, Metastasis and Treatment. In Szczerbicki E, Wojtkiewicz K, Nguyen SV, Pietranik M, Krótkiewicz M, editors, Recent Challenges in Intelligent Information and Database Systems - 14th Asian Conference, ACIIDS 2022, Proceedings. Springer Science and Business Media Deutschland GmbH. 2022. p. 566-577. (Communications in Computer and Information Science). doi: 10.1007/978-981-19-8234-7_44

A Minimal Model of Cancer Growth, Metastasis and Treatment

Abstract

Publication series

Conference

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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