A Framework for Modeling and Efficacy Evaluation of Treatment of Cancer with Metastasis

Jaroslaw Smieja; Krzysztof Psiuk-Maksymowicz; Andrzej Swierniak

doi:10.1007/978-3-030-83704-4_9

A Framework for Modeling and Efficacy Evaluation of Treatment of Cancer with Metastasis

Department of Systems Biology and Engineering (RAU/RAU1)

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

3 Citations (Scopus)

Abstract

The paper is concerned with modeling of tumor growth, taking into account chemo- and radiotherapy and metastasis. The model consists of two compartments, one representing the primary tumor, sensitive to chemo- and radiotherapy and another, representing metastatic tumor. A population of virtual patients is created by sampling model parameters. Kaplan-Meier survival curves are used to analyze the influence of model parameters on treatment efficacy, with one standard treatment protocol.

Original language	English
Title of host publication	Biocybernetics and Biomedical Engineering – Current Trends and Challenges - Proceedings of the 22nd Polish Conference on Biocybernetics and Biomedical Engineering
Editors	Dorota G. Pijanowska, Krzysztof Zieliński, Adam Liebert, Janusz Kacprzyk
Publisher	Springer Science and Business Media Deutschland GmbH
Pages	88-97
Number of pages	10
ISBN (Print)	9783030837037
DOIs	https://doi.org/10.1007/978-3-030-83704-4_9
Publication status	Published - 2022
Event	22nd Polish Conference on Biocybernetics and Biomedical Engineering, PCBBE 2021 - Warsaw, Poland Duration: 19 May 2021 → 21 May 2021

Publication series

Name	Lecture Notes in Networks and Systems
Volume	293
ISSN (Print)	2367-3370
ISSN (Electronic)	2367-3389

Conference

Conference	22nd Polish Conference on Biocybernetics and Biomedical Engineering, PCBBE 2021
Country/Territory	Poland
City	Warsaw
Period	19/05/21 → 21/05/21

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Chemotherapy
Metastasis
Modeling
Radiotherapy

ASJC Scopus subject areas

Control and Systems Engineering
Signal Processing
Computer Networks and Communications

Access to Document

10.1007/978-3-030-83704-4_9

Cite this

Smieja, J., Psiuk-Maksymowicz, K., & Swierniak, A. (2022). A Framework for Modeling and Efficacy Evaluation of Treatment of Cancer with Metastasis. In D. G. Pijanowska, K. Zieliński, A. Liebert, & J. Kacprzyk (Eds.), Biocybernetics and Biomedical Engineering – Current Trends and Challenges - Proceedings of the 22nd Polish Conference on Biocybernetics and Biomedical Engineering (pp. 88-97). (Lecture Notes in Networks and Systems; Vol. 293). Springer Science and Business Media Deutschland GmbH. https://doi.org/10.1007/978-3-030-83704-4_9

Smieja, Jaroslaw ; Psiuk-Maksymowicz, Krzysztof ; Swierniak, Andrzej. / A Framework for Modeling and Efficacy Evaluation of Treatment of Cancer with Metastasis. Biocybernetics and Biomedical Engineering – Current Trends and Challenges - Proceedings of the 22nd Polish Conference on Biocybernetics and Biomedical Engineering. editor / Dorota G. Pijanowska ; Krzysztof Zieliński ; Adam Liebert ; Janusz Kacprzyk. Springer Science and Business Media Deutschland GmbH, 2022. pp. 88-97 (Lecture Notes in Networks and Systems).

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abstract = "The paper is concerned with modeling of tumor growth, taking into account chemo- and radiotherapy and metastasis. The model consists of two compartments, one representing the primary tumor, sensitive to chemo- and radiotherapy and another, representing metastatic tumor. A population of virtual patients is created by sampling model parameters. Kaplan-Meier survival curves are used to analyze the influence of model parameters on treatment efficacy, with one standard treatment protocol.",

keywords = "Chemotherapy, Metastasis, Modeling, Radiotherapy",

author = "Jaroslaw Smieja and Krzysztof Psiuk-Maksymowicz and Andrzej Swierniak",

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Smieja, J , Psiuk-Maksymowicz, K & Swierniak, A 2022, A Framework for Modeling and Efficacy Evaluation of Treatment of Cancer with Metastasis. in DG Pijanowska, K Zieliński, A Liebert & J Kacprzyk (eds), Biocybernetics and Biomedical Engineering – Current Trends and Challenges - Proceedings of the 22nd Polish Conference on Biocybernetics and Biomedical Engineering. Lecture Notes in Networks and Systems, vol. 293, Springer Science and Business Media Deutschland GmbH, pp. 88-97, 22nd Polish Conference on Biocybernetics and Biomedical Engineering, PCBBE 2021, Warsaw, Poland, 19/05/21. https://doi.org/10.1007/978-3-030-83704-4_9

A Framework for Modeling and Efficacy Evaluation of Treatment of Cancer with Metastasis. / Smieja, Jaroslaw ; Psiuk-Maksymowicz, Krzysztof ; Swierniak, Andrzej.
Biocybernetics and Biomedical Engineering – Current Trends and Challenges - Proceedings of the 22nd Polish Conference on Biocybernetics and Biomedical Engineering. ed. / Dorota G. Pijanowska; Krzysztof Zieliński; Adam Liebert; Janusz Kacprzyk. Springer Science and Business Media Deutschland GmbH, 2022. p. 88-97 (Lecture Notes in Networks and Systems; Vol. 293).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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AB - The paper is concerned with modeling of tumor growth, taking into account chemo- and radiotherapy and metastasis. The model consists of two compartments, one representing the primary tumor, sensitive to chemo- and radiotherapy and another, representing metastatic tumor. A population of virtual patients is created by sampling model parameters. Kaplan-Meier survival curves are used to analyze the influence of model parameters on treatment efficacy, with one standard treatment protocol.

KW - Chemotherapy

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BT - Biocybernetics and Biomedical Engineering – Current Trends and Challenges - Proceedings of the 22nd Polish Conference on Biocybernetics and Biomedical Engineering

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A2 - Liebert, Adam

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PB - Springer Science and Business Media Deutschland GmbH

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Y2 - 19 May 2021 through 21 May 2021

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Smieja J , Psiuk-Maksymowicz K , Swierniak A. A Framework for Modeling and Efficacy Evaluation of Treatment of Cancer with Metastasis. In Pijanowska DG, Zieliński K, Liebert A, Kacprzyk J, editors, Biocybernetics and Biomedical Engineering – Current Trends and Challenges - Proceedings of the 22nd Polish Conference on Biocybernetics and Biomedical Engineering. Springer Science and Business Media Deutschland GmbH. 2022. p. 88-97. (Lecture Notes in Networks and Systems). doi: 10.1007/978-3-030-83704-4_9